Yang Shen

TL;DR: This work describes an array of submicrometer gold mushrooms with a FOM reaching ~108, which is comparable to the theoretically predicted upper limit for standard PSPR sensors, and demonstrates the array as a biosensor for detecting cytochrome c and alpha-fetoprotein, suggesting that the array is a promising candidate for label-free biomedical sensing.

TL;DR: An integrated pipline for exploring the expressional and evolutionary dynamics of miRNAs across multiple species is presented, miREvo, an integrated software platform with a graphical user interface (GUI), to process deep-sequencing data of small RNAs and to analyze miRNA sequence and expression evolution based on the multiple-species whole genome alignments (WGAs).

TL;DR: A high-throughput approach, sequencing of psoralen crosslinked, ligated, and selected hybrids (SPLASH), that maps pairwise RNA interactions in vivo with high sensitivity and specificity, genome-wide, highlights the underexplored complexity of RNA interactomes and pave the way to better understanding how RNA organization impacts biology.

TL;DR: It is suggested that there is a high birth rate of new miRNA genes, accompanied by a comparably high death rate in Drosophila, and that a small fraction of surviving miRNAs may later on become moderately or highly expressed.

TL;DR: It is hypothesized that miRNAs may have dual functions -- in gene expression tuning and in expression buffering, and the relative importance of these two functions in evolution is discussed.