Melanie Quintana

TL;DR: Assessment of the utility of pathologic complete response (pCR) for neoadjuvant drug development in human epidermal growth factor receptor 2 (HER2]-positive breast cancer finds that it is associated with substantially longer times to recurrence and death.

TL;DR: With completion of enrollment of the first two drug arms, the DIAN‐TU now plans to add new drugs to the platform, designated as the Next Generation (NexGen) prevention trial.

TL;DR: The investigators used a Bayesian analysis of the treatment effect to ensure that a clinically useful result would be obtained even if traditional approaches for defining statistical significance were impractical.

TL;DR: This framework aims at constructing a risk index based on multiple rare variants within a region by using a Bayesian approach to incorporate model uncertainty in the selection of variants to include in the index as well as the direction of the associated effects.

TL;DR: An integrative Bayesian model uncertainty (iBMU) method, which formally incorporates multiple sources of data via a second‐stage probit model on the probability that any predictor is associated with the outcome of interest, is developed.