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Anne M. Fagan
Researcher at Washington University in St. Louis
Publications - 5
Citations - 688
Anne M. Fagan is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Genome-wide association study & Neuropsychology. The author has an hindex of 5, co-authored 5 publications receiving 517 citations.
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Journal ArticleDOI
Evaluation of Tau Imaging in Staging Alzheimer Disease and Revealing Interactions Between β-Amyloid and Tauopathy
Liang Wang,Tammie L.S. Benzinger,Yi Su,Jon Christensen,Karl A. Friedrichsen,Patricia Aldea,Jonathan McConathy,Nigel J. Cairns,Anne M. Fagan,John C. Morris,Beau M. Ances +10 more
TL;DR: Use of [18F]-AV-1451 has a potential for staging of the preclinical and clinical phases of AD and the associations among β-amyloid, tau, and volume loss are assessed.
Journal ArticleDOI
The DIAN-TU Next Generation Alzheimer's prevention trial: Adaptive design and disease progression model.
Randall J. Bateman,Tammie L.S. Benzinger,Scott M. Berry,David B. Clifford,Cynthia Duggan,Anne M. Fagan,Kathleen Fanning,Martin R. Farlow,Jason Hassenstab,Eric McDade,Susan Mills,Katrina L. Paumier,Melanie Quintana,Stephen Salloway,Anna Santacruz,Lon S. Schneider,Guoqiao Wang,Chengjie Xiong +17 more
TL;DR: With completion of enrollment of the first two drug arms, the DIAN‐TU now plans to add new drugs to the platform, designated as the Next Generation (NexGen) prevention trial.
Genome-wide association study identifies four novel loci associated with Alzheimer's endophenotypes and disease modifiers
Yuetiva Deming,Zeran Li,Manav Kapoor,Oscar Harari,Jorge L. Del-Aguila,Kathleen Black,David Carrell,Yefei Cai,Maria Victoria Fernandez,John P. Budde,Shengmei Ma,Benjamin Saef,Bill Howells,Kuan-lin Huang,Sarah Bertelsen,Anne M. Fagan,David M. Holtzman,John C. Morris,Sungeun Kim,Andrew J. Saykin,Philip L. De Jager,Marilyn S. Albert,Abhay Moghekar,Richard O'Brien,Matthias Riemenschneider,Ronald C. Petersen,Kaj Blennow,Henrik Zetterberg,Lennart Minthon,Vivianna M. Van Deerlin,Virginia M.-Y. Lee,Leslie M. Shaw,John Q. Trojanowski,Gerard D. Schellenberg,Jonathan L. Haines,Richard Mayeux,Margaret A. Pericak-Vance,Lindsay A. Farrer,Elaine R. Peskind,Ge Li,Antonio Fabio Di Narzo,Alzheimer’s Disease Neuroimaging Initiative,John S. K. Kauwe,Alison Goate,Carlos Cruchaga +44 more
TL;DR: Bioinformatics indicate that the intronic SERpinB1 variant affects expression of SERPINB1 in various tissues, including the hippocampus, suggesting that SERPINb1 influences AD through an Aβ-associated mechanism, and can be used to inform future AD studies.
Journal ArticleDOI
Longitudinal β-Amyloid Deposition and Hippocampal Volume in Preclinical Alzheimer Disease and Suspected Non-Alzheimer Disease Pathophysiology.
Brian A. Gordon,Tyler Blazey,Yi Su,Anne M. Fagan,David M. Holtzman,John C. Morris,Tammie L.S. Benzinger +6 more
TL;DR: The rates of Aβ accumulation and loss of hippocampal volume in individuals with SNAP were indistinguishable from those without any pathologic features at baseline, and later preclinical stages (stages 1 and 2+) had elevated A β accumulation.
Journal ArticleDOI
Neuropsychological measures that detect early impairment and decline in preclinical Alzheimer disease
Suzanne E. Schindler,Mateusz S. Jasielec,Hua Weng,Jason Hassenstab,Ellen Grober,Lena McCue,John C. Morris,David M. Holtzman,Chengjie Xiong,Anne M. Fagan +9 more
TL;DR: Which neuropsychological measures in the cognitive battery are most strongly associated with cerebrospinal fluid (CSF) biomarkers of AD brain pathology are evaluated and CSF tau/Aβ42 was associated with baseline performance on 5/9 neuroPsychological measures, especially measures of episodic memory, and longitudinal performance on 7/9 neuroscience measures,especially measures of global cognition.