M
Melina Herman
Researcher at Rockefeller University
Publications - 7
Citations - 1571
Melina Herman is an academic researcher from Rockefeller University. The author has contributed to research in topics: Immunity & Viral replication. The author has an hindex of 7, co-authored 7 publications receiving 1384 citations. Previous affiliations of Melina Herman include French Institute of Health and Medical Research & Paris Descartes University.
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Journal ArticleDOI
Human TRAF3 Adaptor Molecule Deficiency Leads to Impaired Toll-like Receptor 3 Response and Susceptibility to Herpes Simplex Encephalitis
Rebeca Pérez de Diego,Rebeca Pérez de Diego,Rebeca Pérez de Diego,Vanessa Sancho-Shimizu,Vanessa Sancho-Shimizu,Vanessa Sancho-Shimizu,Lazaro Lorenzo,Lazaro Lorenzo,Lazaro Lorenzo,Anne Puel,Anne Puel,Anne Puel,Sabine Plancoulaine,Sabine Plancoulaine,Sabine Plancoulaine,Capucine Picard,Capucine Picard,Melina Herman,Melina Herman,Melina Herman,Annabelle Cardon,Annabelle Cardon,Annabelle Cardon,Anne Durandy,Jacinta Bustamante,Jacinta Bustamante,Jacinta Bustamante,Sivakumar Vallabhapurapu,Jerónimo Bravo,Klaus Warnatz,Yves Chaix,Françoise Cascarrigny,Pierre Lebon,Flore Rozenberg,Michael Karin,Marc Tardieu,Saleh Al-Muhsen,Emmanuelle Jouanguy,Emmanuelle Jouanguy,Emmanuelle Jouanguy,Shen-Ying Zhang,Shen-Ying Zhang,Shen-Ying Zhang,Laurent Abel,Laurent Abel,Laurent Abel,Jean-Laurent Casanova +46 more
TL;DR: Autosomal dominant, human TRAF3 deficiency in a young adult with a history of HSE in childhood is reported, and TLR3-mediated immunity against primary infection by HSV-1 in the central nervous system is critically dependent on TRAf3.
Journal ArticleDOI
Impaired intrinsic immunity to HSV-1 in human iPSC-derived TLR3-deficient CNS cells
Fabien G. Lafaille,Itai M. Pessach,Itai M. Pessach,Shen-Ying Zhang,Shen-Ying Zhang,Michael J. Ciancanelli,Melina Herman,Melina Herman,Avinash Abhyankar,Shui-Wang Ying,Sotirios Keros,Peter A. Goldstein,Gustavo Mostoslavsky,Jose Ordovas-Montanes,Emmanuelle Jouanguy,Emmanuelle Jouanguy,Sabine Plancoulaine,Edmund Y. Tu,Yechiel Elkabetz,Saleh Al-Muhsen,Marc Tardieu,Thorsten M. Schlaeger,George Q. Daley,Laurent Abel,Laurent Abel,Jean-Laurent Casanova,Jean-Laurent Casanova,Lorenz Studer,Luigi D. Notarangelo,Luigi D. Notarangelo +29 more
TL;DR: Impaired TLR3- and UNC-93B-dependent IFN-α/β intrinsic immunity to HSV-1 in the CNS, in neurons and oligodendrocytes in particular, may underlie the pathogenesis of HSE in children with TLR 3-pathway deficiencies.
Journal ArticleDOI
Herpes simplex encephalitis in children with autosomal recessive and dominant TRIF deficiency
Vanessa Sancho-Shimizu,Rebeca Pérez de Diego,Lazaro Lorenzo,Rabih Halwani,Abdullah A. Alangari,Elisabeth Israelsson,Sylvie Fabrega,Annabelle Cardon,Jérome Maluenda,Megumi Tatematsu,Farhad Mahvelati,Melina Herman,Michael J. Ciancanelli,Yiqi Guo,Zobaida Alsum,Nouf Alkhamis,Abdulkarim S. Al-Makadma,Ata Ghadiri,Soraya Boucherit,Sabine Plancoulaine,Capucine Picard,Flore Rozenberg,Marc Tardieu,Pierre Lebon,Emmanuelle Jouanguy,Nima Rezaei,Tsukasa Seya,Misako Matsumoto,Damien Chaussabel,Anne Puel,Shen-Ying Zhang,Laurent Abel,Saleh Al-Muhsen,Jean-Laurent Casanova +33 more
TL;DR: It is suggested that the TRIF-dependent TLR4 and DExD/H-box helicase pathways are largely redundant in host defense and the importance of TRIF for the TLR3-dependent production of antiviral IFNs in the CNS during primary infection with HSV-1 in childhood is demonstrated.
Journal ArticleDOI
Herpes simplex virus encephalitis in a patient with complete TLR3 deficiency: TLR3 is otherwise redundant in protective immunity
Yiqi Guo,Yiqi Guo,Magali Audry,Michael J. Ciancanelli,Laia Alsina,Laia Alsina,Joana Azevedo,Melina Herman,Melina Herman,Esperanza Anguiano,Vanessa Sancho-Shimizu,Lazaro Lorenzo,Elodie Pauwels,Elodie Pauwels,Paul Bastard Philippe,Rebeca Pérez de Diego,Annabelle Cardon,Guillaume Vogt,Capucine Picard,Zafitsara Zo Andrianirina,Flore Rozenberg,Pierre Lebon,Sabine Plancoulaine,Sabine Plancoulaine,Marc Tardieu,Valérie Doireau,Emmanuelle Jouanguy,Emmanuelle Jouanguy,Damien Chaussabel,Damien Chaussabel,Frederic Geissmann,Laurent Abel,Laurent Abel,Jean-Laurent Casanova,Shen-Ying Zhang,Shen-Ying Zhang +35 more
TL;DR: A new autosomal recessive form of completeTLR3 deficiency reveals that human TLR3 is nonredundant in immunity against herpes simplex virus 1 in the central nervous system (CNS) but redundant in host defense against viruses outside the CNS.
Journal ArticleDOI
Heterozygous TBK1 mutations impair TLR3 immunity and underlie herpes simplex encephalitis of childhood
Melina Herman,Michael J. Ciancanelli,Yi Hung Ou,Lazaro Lorenzo,Maja Klaudel-Dreszler,Elodie Pauwels,Vanessa Sancho-Shimizu,Rebeca Pérez de Diego,Avinash Abhyankar,Elisabeth Israelsson,Yiqi Guo,Annabelle Cardon,Flore Rozenberg,Pierre Lebon,Marc Tardieu,Edyta Heropolitańska-Pliszka,Damien Chaussabel,Michael A. White,Laurent Abel,Laurent Abel,Shen-Ying Zhang,Shen-Ying Zhang,Jean-Laurent Casanova,Jean-Laurent Casanova +23 more
TL;DR: Two unrelated children with HSE carry distinct heterozygous mutations in the gene encoding TANK-binding kinase 1, which results in atypical prognosis for both parents.