Daniele Spitaleri

TL;DR: In this article, the authors evaluated the accuracy and feasibility of an objective definition for secondary progressive multiple sclerosis, to enable comparability of future research studies, using MSBase, a large, prospectively acquired, global cohort study, and analyzed the accuracy of 576 data-derived onset definitions for SPM and compared these to a consensus opinion of three neurologists.

TL;DR: To identify predictors of 10‐year Expanded Disability Status Scale (EDSS) change after treatment initiation in patients with relapse‐onset multiple sclerosis, a large number of the predictors were unrelated to treatment initiation.

TL;DR: The results suggest that the disability outcomes based on 3-6-month confirmed disability progression overestimate the accumulation of permanent disability by up to 30%.

TL;DR: Female-to-male ratios stratified by annual relapse count were evaluated across disease duration and patient age and compared between relapse-onset and primary progressive multiple sclerosis, finding decline in relapse activity over time is more closely related to patient age than disease duration.

TL;DR: Propensity score matching effectively minimised baseline covariate imbalance between two directly compared sub-populations from a large observational registry and replicating in a registry dataset derived from “real-world” database the results of the pivotal randomised trial.