M
Mette Kristiansen
Researcher at Aarhus University
Publications - 6
Citations - 2398
Mette Kristiansen is an academic researcher from Aarhus University. The author has contributed to research in topics: Amnionless & Cubilin. The author has an hindex of 6, co-authored 6 publications receiving 2239 citations. Previous affiliations of Mette Kristiansen include French Institute of Health and Medical Research & University of Copenhagen.
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Journal ArticleDOI
Identification of the haemoglobin scavenger receptor.
Mette Kristiansen,Jonas Heilskov Graversen,Christian Jacobsen,Ole Sonne,Hans Jürgen Hoffman,S. K.Alex Law,Søren K. Moestrup +6 more
TL;DR: The identification of the acute phase-regulated and signal-inducing macrophage protein, CD163, as a receptor that scavenges haemoglobin by mediating endocytosis of haptoglobin–haemoglobin complexes is reported.
Journal ArticleDOI
The intrinsic factor-vitamin B12 receptor, cubilin, is a high-affinity apolipoprotein A-I receptor facilitating endocytosis of high-density lipoprotein.
Renata Kozyraki,John C. Fyfe,Mette Kristiansen,Christian Gerdes,Christian Jacobsen,Shiying Cui,Erik Ilsø Christensen,Maria Aminoff,Albert de la Chapelle,Ralf Krahe,Pierre J. Verroust,Søren K. Moestrup +11 more
TL;DR: Cubilin is the intestinal receptor for the endocytosis of intrinsic factor–vitamin B12 and a receptor in epithelial apoA-I/HDL metabolism, and apolipoprotein A-I, the main protein of high-density lipoprotein (HDL), is isolated using cubilin affinity chromatography.
Journal ArticleDOI
The intrinsic factor-vitamin B12 receptor and target of teratogenic antibodies is a megalin-binding peripheral membrane protein with homology to developmental proteins.
Søren K. Moestrup,Renata Kozyraki,Mette Kristiansen,J. H. Kaysen,Hanne H. Rasmussen,Didier Brault,F. Pontillon,F. O. Goda,Erik Ilsø Christensen,Timothy G. Hammond,Pierre J. Verroust +10 more
TL;DR: The present report shows the molecular characterization of the rat 460-kDa epithelial glycoprotein that functions as the receptor facilitating uptake of intrinsic factor-vitamin B12 complexes in the intestine and kidney and proposes the name cubilin for the novel receptor.
Journal ArticleDOI
The human intrinsic factor-vitamin B12 receptor, cubilin: molecular characterization and chromosomal mapping of the gene to 10p within the autosomal recessive megaloblastic anemia (MGA1) region.
Renata Kozyraki,Renata Kozyraki,Renata Kozyraki,Mette Kristiansen,Mette Kristiansen,Mette Kristiansen,Asli Silahtaroglu,Asli Silahtaroglu,Asli Silahtaroglu,Claus Hansen,Claus Hansen,Claus Hansen,Christian Jacobsen,Christian Jacobsen,Christian Jacobsen,Niels Tommerup,Niels Tommerup,Niels Tommerup,Pierre J. Verroust,Pierre J. Verroust,Pierre J. Verroust,Søren K. Moestrup,Søren K. Moestrup,Søren K. Moestrup +23 more
TL;DR: The present molecular and genetic information on human cubilin now provides circumstantial evidence that an impaired synthesis, processing, or ligand binding of cubILin is the molecular background of this hereditary form of megaloblastic anemia.
Journal ArticleDOI
Molecular Dissection of the Intrinsic Factor-Vitamin B12 Receptor, Cubilin, Discloses Regions Important for Membrane Association and Ligand Binding *
Mette Kristiansen,Renata Kozyraki,Christian Jacobsen,Ebba Nexo,Pierre J. Verroust,Søren K. Moestrup +5 more
TL;DR: The N-terminal cubilin region seems crucial for membrane association, whereas the CUB domain cluster harbors distinct sites for ligand binding, according to analysis of conditioned media and cell extracts of transfected cells.