M
Michael Chopin
Researcher at Walter and Eliza Hall Institute of Medical Research
Publications - 47
Citations - 1939
Michael Chopin is an academic researcher from Walter and Eliza Hall Institute of Medical Research. The author has contributed to research in topics: Cellular differentiation & Immune system. The author has an hindex of 20, co-authored 38 publications receiving 1419 citations. Previous affiliations of Michael Chopin include Dresden University of Technology & University of Melbourne.
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Journal ArticleDOI
The transcription factor T-bet is essential for the development of NKp46+ innate lymphocytes via the Notch pathway
Lucille C. Rankin,Lucille C. Rankin,Joanna R Groom,Joanna R Groom,Michael Chopin,Michael Chopin,Marco J Herold,Marco J Herold,Jennifer A. Walker,Lisa A. Mielke,Lisa A. Mielke,Andrew N. J. McKenzie,Sebastian Carotta,Sebastian Carotta,Stephen L. Nutt,Stephen L. Nutt,Gabrielle T. Belz,Gabrielle T. Belz +17 more
TL;DR: This work reports that the transcription factor T-bet (encoded by Tbx21) was essential for the development of NKp46+ ILCs but not of LTi cells or nuocytes, and differentiated solely from the CD4− LTi population, not theCD4+ LTipopulation.
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Nfil3 is required for the development of all innate lymphoid cell subsets
Cyril Seillet,Cyril Seillet,Lucille C. Rankin,Lucille C. Rankin,Joanna R Groom,Joanna R Groom,Lisa A. Mielke,Lisa A. Mielke,Julie Tellier,Julie Tellier,Michael Chopin,Michael Chopin,Nicholas D. Huntington,Nicholas D. Huntington,Gabrielle T. Belz,Gabrielle T. Belz,Sebastian Carotta,Sebastian Carotta +17 more
TL;DR: Loss of Nfil3 selectively reduces Peyer’s patch formation, impairing recruitment and distribution of lymphocytes and compromising immune responses to inflammatory and infectious agents.
Journal ArticleDOI
Innate immunodeficiency following genetic ablation of Mcl1 in natural killer cells
Priyanka Sathe,Rebecca B. Delconte,Fernando Souza-Fonseca-Guimaraes,Cyril Seillet,Michael Chopin,Cassandra J. Vandenberg,Lucille C. Rankin,Lisa A. Mielke,Ingela B Vikstrom,Tatiana B. Kolesnik,Sandra E. Nicholson,Eric Vivier,Mark J. Smyth,Stephen L. Nutt,Stefan P Glaser,Andreas Strasser,Gabrielle T. Belz,Sebastian Carotta,Nicholas D. Huntington +18 more
TL;DR: A non-redundant pathway linking IL-15 to Mcl1 in the maintenance of NK cells and innate immune responses in vivo is demonstrated.
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The transcription factors IRF8 and PU.1 negatively regulate plasma cell differentiation
Sebastian Carotta,Sebastian Carotta,Simon N. Willis,Simon N. Willis,Jhagvaral Hasbold,Jhagvaral Hasbold,Michael Inouye,Michael Inouye,Swee Heng Milon Pang,Swee Heng Milon Pang,Dianne Emslie,Amanda Light,Michael Chopin,Michael Chopin,Wei Shi,Wei Shi,Hongsheng Wang,Herbert C. Morse,David M. Tarlinton,David M. Tarlinton,Lynn M. Corcoran,Lynn M. Corcoran,Philip D. Hodgkin,Philip D. Hodgkin,Stephen L. Nutt,Stephen L. Nutt +25 more
TL;DR: It is shown that the interaction between IRF8 and PU.1 controls the propensity of B cells to undergo class-switch recombination and plasma cell differentiation by concurrently promoting the expression of BCL6 and PAX5 and repressing AID and BLIMP-1.
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Genome-wide DNA methylation analysis identifies hypomethylated genes regulated by FOXP3 in human regulatory T cells
Yuxia Zhang,Yuxia Zhang,Jovana Maksimovic,Gaetano Naselli,Junyan Qian,Michael Chopin,Michael Chopin,Marnie E. Blewitt,Marnie E. Blewitt,Alicia Oshlack,Leonard C. Harrison,Leonard C. Harrison +11 more
TL;DR: It was shown that increased expression of the immune suppressive receptor T-cell immunoglobulin and immunoreceptor tyrosine-based inhibitory motif domain (TIGIT), which delineated Treg from activated effector T cells, was associated with hypomethylation and FOXP3 binding at the TIGIT locus.