M
Michael D. Cole
Researcher at Anglia Ruskin University
Publications - 122
Citations - 4748
Michael D. Cole is an academic researcher from Anglia Ruskin University. The author has contributed to research in topics: Gene & Transactivation. The author has an hindex of 34, co-authored 121 publications receiving 4309 citations. Previous affiliations of Michael D. Cole include Dartmouth–Hitchcock Medical Center & University of Strathclyde.
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Journal ArticleDOI
Breast cancer risk–associated SNPs modulate the affinity of chromatin for FOXA1 and alter gene expression
Richard Cowper-Sal·lari,Xiaoyang Zhang,Jason Wright,Swneke D. Bailey,Swneke D. Bailey,Michael D. Cole,Jérôme Eeckhoute,Jérôme Eeckhoute,Jason H. Moore,Mathieu Lupien,Mathieu Lupien +10 more
TL;DR: The results show that breast cancer risk–associated SNPs are enriched in the cistromes of FOXA1 and ESR1 and the epigenome of histone H3 lysine 4 monomethylation in a cancer- and cell type–specific manner.
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Upregulation of c-MYC in cis through a Large Chromatin Loop Linked to a Cancer Risk-Associated Single-Nucleotide Polymorphism in Colorectal Cancer Cells
TL;DR: The findings of these studies support a mechanism for intergenic SNPs that can promote cancer through the regulation of distal genes by utilizing preexisting large chromatin loops.
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Subunit Composition and Substrate Specificity of a MOF-containing Histone Acetyltransferase Distinct from the Male-specific Lethal (MSL) Complex *
Yong Cai,Jingji Jin,Selene K. Swanson,Michael D. Cole,Seung H. Choi,Laurence Florens,Michael P. Washburn,Michael P. Washburn,Joan W. Conaway,Joan W. Conaway,Ronald C. Conaway,Ronald C. Conaway +11 more
TL;DR: An analysis of the subunit composition and substrate specificity of the NSL complex reveals that NSL is composed of nine subunits, and shows that assembly of the MOF HAT into MSL or NSL complexes controls its substrate specificity.
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Mechanism of transcriptional activation by the Myc oncoproteins.
TL;DR: This review summarizes recent advances in understanding the function of Myc as a transcriptional activator and the role of this activity in Myc biological activities.
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Transcription-independent functions of MYC: regulation of translation and DNA replication.
TL;DR: Recently, MYC was shown to control protein expression through mRNA translation and to directly regulate DNA replication, thus initiating exciting new areas of oncogene research.