M
Michael E. Cusick
Researcher at Harvard University
Publications - 7
Citations - 667
Michael E. Cusick is an academic researcher from Harvard University. The author has contributed to research in topics: Viral pathogenesis & Viral structural protein. The author has an hindex of 6, co-authored 7 publications receiving 631 citations. Previous affiliations of Michael E. Cusick include University of Rome Tor Vergata.
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The Yeast Proteome Database (YPD) and Caenorhabditis elegans Proteome Database (WormPD): comprehensive resources for the organization and comparison of model organism protein information
Maria C. Costanzo,Jennifer D. Hogan,Michael E. Cusick,Brian P. Davis,Ann M. Fancher,Peter E. Hodges,Pinar Kondu,Carey Lengieza,Jodi E. Lew-Smith,Carol Lingner,Kevin J. Roberg-Perez,Michael Tillberg,Joan E. Brooks,James I. Garrels +13 more
TL;DR: YPD is extended to create a database containing complete proteome information about the model organism Caenorhabditis elegans (WormPDtrade mark), and YPD and WormPD are designed for use not only by their respective research communities but also by the broader scientific community.
Journal ArticleDOI
VirusMINT: a viral protein interaction database
Andrew Chatr-aryamontri,Arnaud Ceol,Daniele Peluso,Aurelio Pio Nardozza,Simona Panni,Francesca Sacco,Michele Tinti,Alex Smolyar,Luisa Castagnoli,Marc Vidal,Michael E. Cusick,Gianni Cesareni +11 more
TL;DR: The VirusMINT database aims at collecting all protein interactions between viral and human proteins reported in the literature, and currently stores over 5000 interactions involving more than 490 unique viral proteins from more than 110 different viral strains.
Journal ArticleDOI
Viral Perturbations of Host Networks Reflect Disease Etiology
Natali Gulbahce,Han Yan,Amélie Dricot,Megha Padi,Danielle Byrdsong,Rachel Franchi,Deok-Sun Lee,Deok-Sun Lee,Orit Rozenblatt-Rosen,Jessica C. Mar,Michael A. Calderwood,Amy Baldwin,Amy Baldwin,Bo Zhao,Balaji Santhanam,Pascal Braun,Nicolas Simonis,Nicolas Simonis,Kyung-Won Huh,Kyung-Won Huh,Karin Hellner,Miranda Grace,Alyce A. Chen,Renee Rubio,Jarrod A. Marto,Nicholas A. Christakis,Elliott Kieff,Frederick P. Roth,Jennifer Roecklein-Canfield,Jennifer Roecklein-Canfield,James A. DeCaprio,Michael E. Cusick,John Quackenbush,David E. Hill,Karl Münger,Marc Vidal,Albert-László Barabási,Albert-László Barabási +37 more
TL;DR: In this article, the authors examined whether viral perturbations of host interactome may underlie such virally implicated disease relationships, using as models two different human viruses, Epstein-Barr virus (EBV) and human papillomavirus (HPV).
Journal ArticleDOI
An inter-species protein-protein interaction network across vast evolutionary distance.
Quan Zhong,Quan Zhong,Samuel J. Pevzner,Tong Hao,Yang Wang,Roberto Mosca,Jörg Menche,Jörg Menche,Mikko Taipale,Murat Tasan,Changyu Fan,Xinping Yang,P.J. Haley,Ryan R. Murray,Flora Mer,Fana Gebreab,Stanley Tam,Andrew MacWilliams,Amélie Dricot,Patrick Reichert,Balaji Santhanam,Lila Ghamsari,Michael A. Calderwood,Thomas Rolland,Benoit Charloteaux,Susan Lindquist,Albert-László Barabási,Albert-László Barabási,Albert-László Barabási,David E. Hill,Patrick Aloy,Michael E. Cusick,Yu Xia,Yu Xia,Frederick P. Roth,Marc Vidal +35 more
TL;DR: Although substantially reduced relative to intra‐species networks, the levels of functional overlap in the yeast–human inter‐interactome network uncover significant remnants of co‐functionality widely preserved in the two proteomes beyond human–yeast homologs.
An inter-species protein-protein interaction network across vast evolutionary distance
Quan Zhong,Quan Zhong,Samuel J. Pevzner,Tong Hao,Yang Wang,Roberto Mosca,Jörg Menche,Jörg Menche,Mikko Taipale,Murat Tasan,Changyu Fan,Xinping Yang,P.J. Haley,Ryan R. Murray,Flora Mer,Fana Gebreab,Stanley Tam,Andrew MacWilliams,Amélie Dricot,Patrick Reichert,Balaji Santhanam,Lila Ghamsari,Michael A. Calderwood,Thomas Rolland,Benoit Charloteaux,Susan Lindquist,Albert-László Barabási,Albert-László Barabási,Albert-László Barabási,David E. Hill,Patrick Aloy,Michael E. Cusick,Yu Xia,Yu Xia,Frederick P. Roth,Marc Vidal +35 more
TL;DR: In this article, the authors investigate how biophysical and functional networks are coordinated, whether all biophysical interactions correspond to functional interactions, and how such biophysical-versus-functional network coordination is shaped by evolutionary forces.