N
Natali Gulbahce
Researcher at University of California, San Francisco
Publications - 52
Citations - 7599
Natali Gulbahce is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Genome & Genomics. The author has an hindex of 23, co-authored 49 publications receiving 6456 citations. Previous affiliations of Natali Gulbahce include Northeastern University & California Institute for Quantitative Biosciences.
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Journal ArticleDOI
Network Medicine: A Network-Based Approach to Human Disease
TL;DR: Advances in this direction are essential for identifying new disease genes, for uncovering the biological significance of disease-associated mutations identified by genome-wide association studies and full-genome sequencing, and for identifying drug targets and biomarkers for complex diseases.
Journal ArticleDOI
Global landscape of HIV-human protein complexes
Stefanie Jäger,Peter Cimermancic,Peter Cimermancic,Natali Gulbahce,Natali Gulbahce,Jeffrey R. Johnson,Jeffrey R. Johnson,Jeffrey R. Johnson,Kathryn E. McGovern,Kathryn E. McGovern,Starlynn Clarke,Michael Shales,Michael Shales,Gaelle Mercenne,Lars Pache,Kathy H. Li,Kathy H. Li,Hilda Hernandez,Hilda Hernandez,Gwendolyn M. Jang,Gwendolyn M. Jang,Shoshannah L. Roth,Eyal Akiva,Eyal Akiva,John M. Marlett,Melanie L. Stephens,Iván D'Orso,Iván D'Orso,Jason D Fernandes,Marie E. Fahey,Marie E. Fahey,Cathal Mahon,Cathal Mahon,Anthony J. O’Donoghue,Aleksandar Todorovic,John H. Morris,David Maltby,Tom Alber,Gerard Cagney,Frederic D. Bushman,John A. T. Young,Sumit K. Chanda,Wesley I. Sundquist,Tanja Kortemme,Tanja Kortemme,Ryan D. Hernandez,Ryan D. Hernandez,Charles S. Craik,Charles S. Craik,Alma L. Burlingame,Alma L. Burlingame,Andrej Sali,Alan D. Frankel,Alan D. Frankel,Nevan J. Krogan +54 more
TL;DR: The use of affinity tagging and purification mass spectrometry is reported to determine systematically the physical interactions of all 18 HIV-1 proteins and polyproteins with host proteins in two different human cell lines (HEK293 and Jurkat).
Journal ArticleDOI
Extensive sequencing of seven human genomes to characterize benchmark reference materials
Justin M. Zook,David Catoe,Jennifer McDaniel,Lindsay K. Vang,Noah Spies,Noah Spies,Arend Sidow,Ziming Weng,Yuling Liu,Christopher E. Mason,Noah Alexander,Elizabeth Henaff,Alexa B. R. McIntyre,Dhruva Chandramohan,Feng Chen,Erich Jaeger,Ali Moshrefi,Khoa Pham,William Stedman,Tiffany Y. Liang,Michael Saghbini,Zeljko Dzakula,Alex Hastie,Han Cao,Gintaras Deikus,Eric E. Schadt,Robert Sebra,Ali Bashir,R Truty,Christopher C. Chang,Natali Gulbahce,Keyan Zhao,Srinka Ghosh,Fiona Hyland,Yutao Fu,Mark Chaisson,Chunlin Xiao,Jonathan Trow,Stephen T. Sherry,Alexander Wait Zaranek,Madeleine Ball,Jason Bobe,Preston W. Estep,George M. Church,Patrick Marks,Sofia Kyriazopoulou-Panagiotopoulou,Grace X.Y. Zheng,Michael Schnall-Levin,Heather Ordonez,Patrice A Mudivarti,Kristina Giorda,Ying Sheng,Karoline Bjarnesdatter Rypdal,Marc L. Salit,Marc L. Salit +54 more
TL;DR: A large, diverse set of sequencing data for seven human genomes is described; five are current or candidate NIST Reference Materials and two Personal Genome Project trios, one of Ashkenazim Jewish ancestry and one of Chinese ancestry are described.
Journal ArticleDOI
Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins
Orit Rozenblatt-Rosen,Rahul C. Deo,Rahul C. Deo,Megha Padi,Guillaume Adelmant,Michael A. Calderwood,Thomas Rolland,Miranda Grace,Miranda Grace,Amélie Dricot,Manor Askenazi,Maria Tavares,Sam Pevzner,Sam Pevzner,Fieda Abderazzaq,Danielle Byrdsong,Anne-Ruxandra Carvunis,Alyce A. Chen,Alyce A. Chen,Jingwei Cheng,Jingwei Cheng,Mick Correll,Melissa Duarte,Melissa Duarte,Changyu Fan,Mariet C.W. Feltkamp,Scott B. Ficarro,Rachel Franchi,Rachel Franchi,Brijesh K. Garg,Natali Gulbahce,Tong Hao,Amy M. Holthaus,Amy M. Holthaus,Robert James,Anna Korkhin,Anna Korkhin,Larisa Litovchick,Larisa Litovchick,Jessica C. Mar,Theodore R. Pak,Sabrina Rabello,Renee Rubio,Yun Shen,Saurav Singh,Jennifer M. Spangle,Jennifer M. Spangle,Murat Tasan,Murat Tasan,Shelly Wanamaker,Shelly Wanamaker,James T. Webber,Jennifer Roecklein-Canfield,Jennifer Roecklein-Canfield,Eric Johannsen,Eric Johannsen,Albert-László Barabási,Rameen Beroukhim,Rameen Beroukhim,Rameen Beroukhim,Elliott Kieff,Elliott Kieff,Michael E. Cusick,David E. Hill,Karl Münger,Karl Münger,Jarrod A. Marto,John Quackenbush,Frederick P. Roth,James A. DeCaprio,James A. DeCaprio,Marc Vidal +71 more
TL;DR: It is shown that systematic analyses of host targets of viral proteins can identify cancer genes with a success rate on a par with their identification through functional genomics and large-scale cataloguing of tumour mutations, to increase the specificity of cancer gene identification.
Journal ArticleDOI
MicroRNA-21 Integrates Pathogenic Signaling to Control Pulmonary Hypertension Results of a Network Bioinformatics Approach
Victoria N. Parikh,Richard C. Jin,Sabrina Rabello,Natali Gulbahce,Kevin P. White,Andrew E. Hale,Katherine A. Cottrill,Rahamthulla S. Shaik,Aaron B. Waxman,Ying-Yi Zhang,Bradley A. Maron,Jochen C. Hartner,Yuko Fujiwara,Stuart H. Orkin,Kathleen J. Haley,Albert-László Barabási,Joseph Loscalzo,Stephen Y. Chan +17 more
TL;DR: In this article, microRNA-21 (miR-21) is predicted as a PH-modifying microRNA, regulating targets integral to bone morphogenetic protein (BMP) and Rho/Rho-kinase signaling as well as functional pathways associated with hypoxia, inflammation, and genetic haploinsufficiency of BMP receptor type 2.