Lila Ghamsari

TL;DR: The map uncovers significant interconnectivity between known and candidate cancer gene products, providing unbiased evidence for an expanded functional cancer landscape, while demonstrating how high-quality interactome models will help "connect the dots" of the genomic revolution.

TL;DR: An analysis of protein-protein interactions in Arabidopsis identifies the plant interactome and demonstrated plant immune system functions for 15 of 17 tested host proteins that interact with effectors from both pathogens.

TL;DR: This work describes the production of a sequence-confirmed, clonal collection of over 16,100 human open-reading frames encoded in a versatile Gateway vector system, thereby enabling both targeted experiments and high-throughput screens in diverse cell types.

TL;DR: This work cloned full-length open reading frames of alternatively spliced transcripts for a large number of human genes and used protein-protein interaction profiling to functionally compare hundreds of protein isoform pairs, revealing a widespread expansion of protein interaction capabilities through alternative splicing and suggesting that many alternative "isoforms" are functionally divergent (i.e., "functional alloforms").

TL;DR: A systematic protein-protein interaction network of virulence effectors from the ascomycete pathogen Golovinomyces orontii and Arabidopsis thaliana host proteins is generated and suggests the existence of a molecular host-pathogen interface that is conserved acrossArabidopsis accessions, while evolutionary adaptation occurs in the immediate network neighborhood of effector targets.