Michael Goggins

TL;DR: CTCs labeling with one or more markers of TICs are found in a majority of patients with PDAC and are independently predictive of decreased disease-free and overall survival.

TL;DR: The role of germline FA gene mutations in kindred in which several family members had pancreatic cancer is determined and published data suggest the possibility that although germline and somatic mutations in FANCC and FANCG may contribute to the occurrence of pancreatic cancers, the Pancreatic cancers that arise do so in an apparent sporadic fashion rather than with a phenotype of familial pancreaticcancer.

TL;DR: A 19-year-old woman with an aggressive lymphoma received a bone marrow transplant from her sister three and a half years later subcutaneous panniculitic T-cell lymphoma was diagnosed in the donor; the same rare tumor appeared in the recipient four and ahalf years after transplantation.

TL;DR: P53 protein expression was confined to invasive pancreatic adenocarcinoma cells and was not expressed in cancer-associated fibroblasts, finding no evidence that pancreatic cancer associated fibro Blasts harbor somatic copy number changes or immunohistochemical evidence of p53 mutations.

TL;DR: Further advances in pancreatic cancer molecular genetics are needed to facilitate the development of molecular screening tests, to identify additional familial susceptibility genes, and to identify targets for rational therapeutic targeting.