M
Michael Goggins
Researcher at Johns Hopkins University
Publications - 378
Citations - 52451
Michael Goggins is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Pancreatic cancer & Cancer. The author has an hindex of 111, co-authored 358 publications receiving 45785 citations. Previous affiliations of Michael Goggins include Johns Hopkins University School of Medicine & Fred Hutchinson Cancer Research Center.
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Journal ArticleDOI
Mutant TP53 in Duodenal Samples of Pancreatic Juice from Patients with Pancreatic Cancer or High-Grade Dysplasia
Mitsuro Kanda,Yoshihiko Sadakari,Michael Borges,Mark Topazian,James J. Farrell,Sapna Syngal,Jeffrey E. Lee,Ihab R. Kamel,Anne Marie Lennon,Spencer Knight,Sho Fujiwara,Ralph H. Hruban,Marcia I. Canto,Michael Goggins +13 more
TL;DR: The authors detected mutant TP53 in secretin-stimulated pancreatic juice samples collected from duodena of patients with high-grade dysplasia or invasive pancreatic cancer.
Journal ArticleDOI
The glycan CA19-9 promotes pancreatitis and pancreatic cancer in mice
Dannielle D. Engle,Dannielle D. Engle,Hervé Tiriac,Hervé Tiriac,Keith Rivera,Arnaud Pommier,Arnaud Pommier,Sean Whalen,Tobiloba E. Oni,Tobiloba E. Oni,Brinda Alagesan,Brinda Alagesan,Eun Jung Lee,Eun Jung Lee,Melissa Yao,Melissa Yao,Matthew S. Lucito,Matthew S. Lucito,Benjamin Spielman,Benjamin Spielman,Brandon Da Silva,Brandon Da Silva,Christina Schoepfer,Christina Schoepfer,Kevin Wright,Kevin Wright,Brianna Creighton,Brianna Creighton,Lauren Afinowicz,Lauren Afinowicz,Kenneth H. Yu,Kenneth H. Yu,Robert Grützmann,Daniela Aust,Phyllis A. Gimotty,Katherine S. Pollard,Katherine S. Pollard,Ralph H. Hruban,Michael Goggins,Christian Pilarsky,Young-Kyu Park,Young-Kyu Park,Darryl J. Pappin,Michael A. Hollingsworth,David A. Tuveson,David A. Tuveson +45 more
TL;DR: CA19-9 may be more than an innocent bystander that marks the presence of pancreatic disease; it may play a causal role in disease and be nominated as a therapeutic target.
Journal ArticleDOI
Prevention and management of duodenal polyps in familial adenomatous polyposis
Lodewijk A.A. Brosens,J J Keller,J J Keller,G. J. A. Offerhaus,G. J. A. Offerhaus,Michael Goggins,F M Giardiello +6 more
TL;DR: The clinicopathological features, management, and prevention of duodenal neoplasia in patients with familial adenomatous polyposis and the lifetime risk of colorectal carcinoma is virtually 100% if patients are not treated by colectomy is discussed.
Journal ArticleDOI
Pancreatic cancer incidence trends: evidence from the Surveillance, Epidemiology and End Results (SEER) population-based data.
TL;DR: Many of the trends parallel changing prevalence of lifestyle risk factors such as smoking, overweight and obesity, and diabetes in the USA, particularly for pancreatic adenocarcinoma, and improved diagnosis methods during the past 40 years.
Journal ArticleDOI
Immunohistochemical validation of a novel epithelial and a novel stromal marker of pancreatic ductal adenocarcinoma identified by global expression microarrays: sea urchin fascin homolog and heat shock protein 47.
Anirban Maitra,Christine A. Iacobuzio-Donahue,Ayman Rahman,Taylor A. Sohn,Peter Argani,Renee Meyer,Charles J. Yeo,John L. Cameron,Michael Goggins,Scott E. Kern,Raheela Ashfaq,Ralph H. Hruban,Robb E. Wilentz +12 more
TL;DR: Finn and HSP47 are novel tumor markers with potential diagnostic and therapeutic implications for pancreatic carcinoma and establish the usefulness of global expression platforms to identify novel tumor marker markers.