M
Michael Goggins
Researcher at Johns Hopkins University
Publications - 378
Citations - 52451
Michael Goggins is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Pancreatic cancer & Cancer. The author has an hindex of 111, co-authored 358 publications receiving 45785 citations. Previous affiliations of Michael Goggins include Johns Hopkins University School of Medicine & Fred Hutchinson Cancer Research Center.
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Journal ArticleDOI
Association of common susceptibility variants of pancreatic cancer in higher-risk patients: A PACGENE study
Erica J. Childs,Kari G. Chaffee,Steven Gallinger,Sapna Syngal,Ann G. Schwartz,Michele L. Cote,Melissa L. Bondy,Ralph H. Hruban,Stephen J. Chanock,Robert N. Hoover,Charles S. Fuchs,David N. Rider,Laufey T. Amundadottir,Rachael Z. Stolzenberg-Solomon,Brian M. Wolpin,Harvey A. Risch,Michael Goggins,Gloria M. Petersen,Alison P. Klein +18 more
TL;DR: The role of genetic variants previously associated with risk of pancreatic, breast, ovarian, or prostate cancer are examined and suggestive evidence of association to pancreatic cancer is found for SNPs at HDAC9 (7p21.1) and COL6A2 (21q22.3).
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Pancreatic Cancer Chemoprevention Translational Workshop: Meeting Report
Mark Steven Miller,Peter J. Allen,Teresa A. Brentnall,Michael Goggins,Ralph H. Hruban,Gloria M. Petersen,Chinthalapally V. Rao,David C. Whitcomb,Randall E. Brand,Suresh T. Chari,Alison P. Klein,David M. Lubman,Andrew D. Rhim,Diane M. Simeone,Brian M. Wolpin,Asad Umar,Sudhir Srivastava,Vernon E. Steele,Jo Ann Rinaudo +18 more
TL;DR: The meeting participants recommended the development of an National Cancer Institute working group to coordinate efforts, provide a framework, and identify opportunities for chemoprevention of pancreatic cancer.
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Epigenetic silencing of EYA2 in pancreatic adenocarcinomas promotes tumor growth
Audrey Vincent,Seung-Mo Hong,Chaoxin Hu,Noriyuki Omura,Angela Young,Haeryoung Kim,Jun Yu,Spencer Knight,Michael Ayars,Margaret Griffith,Isabelle Van Seuningen,Anirban Maitra,Michael Goggins +12 more
TL;DR: The role of epigenetic mechanisms of EYA2 gene silencing in pancreatic cancers, performed in vitro and in vivo proliferation and migration assays to assess the effect of Eya2 silencing on tumor cell growth and metastasis formation, and expression analysis to identify genes transcriptionally regulated by EYA 2 were investigated.
Journal ArticleDOI
The Multicenter Cancer of Pancreas Screening Study: Impact on Stage and Survival
Mohamad Dbouk,Bryson W. Katona,Randall E. Brand,Amitabh Chak,Sapna Syngal,James J. Farrell,Fay Kastrinos,Elena M. Stoffel,Amanda L. Blackford,Anil K. Rustgi,Beth Dudley,Linda S. Lee,Ankit Chhoda,Richard S. Kwon,Gregory G. Ginsberg,Alison P. Klein,Ihab R. Kamel,Ralph H. Hruban,Jin He,Eun Ji Shin,Anne Marie Lennon,Marcia I. Canto,Michael Goggins +22 more
TL;DR: Most pancreatic cancers diagnosed within the CAPS high-risk cohort in the recent years have had stage I disease with long-term survival.
Journal ArticleDOI
Molecular genetics and related developments in pancreatic cancer.
TL;DR: It is believed that an improved knowledge of the molecular genetics of pancreatic cancer will lead to the development of a new generation of rational and more effective treatments.