M
Michael Goggins
Researcher at Johns Hopkins University
Publications - 378
Citations - 52451
Michael Goggins is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Pancreatic cancer & Cancer. The author has an hindex of 111, co-authored 358 publications receiving 45785 citations. Previous affiliations of Michael Goggins include Johns Hopkins University School of Medicine & Fred Hutchinson Cancer Research Center.
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Journal ArticleDOI
Somatic mutations in the chromatin remodeling gene ARID1A occur in several tumor types.
Siân Jones,Meng Li,D. Williams Parsons,Xiaosong Zhang,Jelle Wesseling,Petra Kristel,Marjanka K. Schmidt,Sanford D. Markowitz,Hai Yan,Darell D. Bigner,Ralph H. Hruban,James R. Eshleman,Christine A. Iacobuzio-Donahue,Michael Goggins,Anirban Maitra,Sami N. Malek,Steve M. Powell,Bert Vogelstein,Kenneth W. Kinzler,Victor E. Velculescu,Nickolas Papadopoulos +20 more
TL;DR: It is suggested that the aberrant chromatin remodeling consequent to ARID1A inactivation contributes to a variety of different types of neoplasms.
Journal ArticleDOI
Serum Macrophage Inhibitory Cytokine 1 as a Marker of Pancreatic and Other Periampullary Cancers
Jens Koopmann,Phillip Buckhaults,David Brown,Marianna Zahurak,Norihiro Sato,Noriyoshi Fukushima,Lori J. Sokoll,Daniel W. Chan,Charles J. Yeo,Ralph H. Hruban,Samuel N. Breit,Kenneth W. Kinzler,Bert Vogelstein,Michael Goggins +13 more
TL;DR: Serum MIC-1 measurement can aid in the diagnosis of pancreatic adenocarcinoma and the identification of accurate, noninvasive diagnostic markers that would enable earlier diagnosis of symptomatic patients and earlier detection of cancer in asymptomatic individuals at high risk for developing pancreatic cancer.
Journal ArticleDOI
The Prevalence of BRCA2 Mutations in Familial Pancreatic Cancer
Fergus J. Couch,Michele Johnson,Kari G. Rabe,Kieran Brune,Mariza de Andrade,Michael Goggins,Heidi Rothenmund,Steven Gallinger,Alison P. Klein,Gloria M. Petersen,Ralph H. Hruban +10 more
TL;DR: A total of 10 carriers from 180 families were identified, suggesting that BRCA2 mutations account for 6% of moderate and high-risk pancreatic cancer families, suggesting a link between breast and ovarian cancer and family history.
Journal ArticleDOI
Genetic, Immunohistochemical, and Clinical Features of Medullary Carcinoma of the Pancreas : A Newly Described and Characterized Entity
Robb E. Wilentz,Michael Goggins,Mark Redston,Victoria Marcus,N. Volkan Adsay,Taylor A. Sohn,Shri Hari S. Kadkol,Charles J. Yeo,Michael A. Choti,Marianna Zahurak,Karen A. Johnson,M. Tascilar,G. Johan A. Offerhaus,Ralph H. Hruban,Scott E. Kern +14 more
TL;DR: Recognition of the medullary variant of pancreatic adenocarcinoma is important because of its special genetic, immunohistochemical, and clinical features, and only by classifyingmedullary carcinoma as special subset of adenOCarcinomas can it hope to further elucidate its unique pathogenesis.
Journal ArticleDOI
The Human MitoChip: A High-Throughput Sequencing Microarray for Mitochondrial Mutation Detection
Anirban Maitra,Yoram Cohen,Susannah E.D. Gillespie,Elizabeth Mambo,Noriyoshi Fukushima,Mohammad O. Hoque,Nila Shah,Michael Goggins,Joseph A. Califano,David Sidransky,Aravinda Chakravarti +10 more
TL;DR: The MitoChip is a high-throughput sequencing tool for the reliable identification of mitochondrial DNA mutations from primary tumors in clinical samples and detected at least one cancer-associated mitochondrial mutation in six (66%) of nine samples.