M
Michael Goggins
Researcher at Johns Hopkins University
Publications - 378
Citations - 52451
Michael Goggins is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Pancreatic cancer & Cancer. The author has an hindex of 111, co-authored 358 publications receiving 45785 citations. Previous affiliations of Michael Goggins include Johns Hopkins University School of Medicine & Fred Hutchinson Cancer Research Center.
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Journal ArticleDOI
Molecular Determinants of Retinoic Acid Sensitivity in Pancreatic Cancer
Sonal Gupta,Dipankar Pramanik,Radha Mukherjee,Nathaniel R. Campbell,Sathyanarayanan Elumalai,Roeland F. de Wilde,Seung-Mo Hong,Seung-Mo Hong,Michael Goggins,Ana De Jesus-Acosta,Daniel A. Laheru,Anirban Maitra +11 more
TL;DR: The widely used agent ATRA deserves a “second look” in PDAC, but needs to be targeted to patient subsets with biopsy-proven FABP5-negative tumors, or be combined with a chromatin-modifying agent to reexpress endogenous CRABP2.
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KRAS and guanine nucleotide-binding protein mutations in pancreatic juice collected from the duodenum of patients at high risk for neoplasia undergoing endoscopic ultrasound.
James R. Eshleman,Alexis L. Norris,Yoshihiko Sadakari,Marija Debeljak,Michael Borges,Colleen T. Harrington,Elaine Lin,Aaron Brant,Thomas Barkley,J. Alejandro Almario,Mark Topazian,James J. Farrell,Sapna Syngal,Jeffrey H. Lee,Jun Yu,Ralph H. Hruban,Mitsuro Kanda,Marcia I. Canto,Michael Goggins +18 more
TL;DR: Mutations detected in individuals without pancreatic abnormalities, based on imaging analyses, likely arise from small pancreatic intraepithelial neoplasia lesions.
Journal ArticleDOI
Gene expression alterations in the non-neoplastic parenchyma adjacent to infiltrating pancreatic ductal adenocarcinoma.
Noriyoshi Fukushima,Jens Koopmann,Norihiro Sato,Nijaguna B. Prasad,Ralph Carvalho,Steven D. Leach,Ralph H. Hruban,Michael Goggins +7 more
TL;DR: Some of the molecular alterations in acinar cells that occur in response to adjacent infiltrating pancreatic ductal adenocarcinoma are demonstrated and reveal that such alterations can provide a rich source of markers of pancreatic cancer.
Journal ArticleDOI
The chemokine receptor CXCR4 is regulated by DNA methylation in pancreatic cancer.
TL;DR: It is demonstrated that DNAmethylation influences CXCR4 expression in human pancreatic cancer, the first evidence for epigenetic regulation of CX CR4 in human cancers, providing new insights into the role of C XCR4/CXCL12 interactions in tumor progression.
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Large-scale allelotype of pancreaticobiliary carcinoma provides quantitative estimates of genome-wide allelic loss.
Christine A. Iacobuzio-Donahue,Michiel S. van der Heijden,Mark R. Baumgartner,William J. Troup,Jane Romm,Kimberly Doheny,Elizabeth Pugh,Charles J. Yeo,Michael Goggins,Ralph H. Hruban,Scott E. Kern +10 more
TL;DR: The comprehensive allelotype of 82 xenografted pancreatic or biliary cancers is presented using 386 microsatellite markers and spanning the entire genome at an average coverage of 10 cM, and the first distance-based estimates of chromosome material lost in a human epithelial cancer are provided.