Joseph A. Carcillo

TL;DR: Severe sepsis is a common, expensive, and frequently fatal condition, with as many deaths annually as those from acute myocardial infarction, and is especially common in the elderly and is likely to increase substantially as the U.S. population ages.

TL;DR: An unexpected increase in mortality coincident with CPOE implementation is observed, which suggests that when implementing C POE systems, institutions should continue to evaluate mortality effects, in addition to medication error rates, for children who are dependent on time-sensitive therapies.

TL;DR: The 2007 update of the 2002 American College of Critical Care Medicine Clinical Guidelines for Hemodynamic Support of Neonates and Children with Septic Shock continues to emphasize early use of age-specific therapies to attain time-sensitive goals, and a major new recommendation in the 2007 update is earlier use of inotrope support through peripheral access until central access is attained.

TL;DR: Severe sepsis is a significant health problem in children and is associated with the use of extensive healthcare resources, and the mean length of stay and cost were 31 days and $40,600, respectively.

TL;DR: A major new recommendation in the 2014 update of the 2007 American College of Critical Care Medicine “Clinical Guidelines for Hemodynamic Support of Neonates and Children with Septic Shock” is consideration of institution—specific use of a recognition bundle containing a trigger tool for rapid identification of patients with septic shock.