Michael Lankerovich

TL;DR: The Ivy Glioblastoma Atlas is presented, an anatomically based transcriptional atlas of human gliOBlastoma that aligns individual histologic features with genomic alterations and gene expression patterns, thus assigning molecular information to the most important morphologic hallmarks of the tumor.

TL;DR: This study highlights the prevalence of gene fusions as one of the major genomic abnormalities in GBM as a small subset of patients with fusions of receptor tyrosine kinases can benefit from existing FDA approved drugs and drugs available in various clinical trials.

TL;DR: It is shown that gene expression varies considerably by anatomic feature and cancer stem cell population, exhibiting molecular signatures that are more highly conserved within tumors than between tumors, and reflecting the cell types and microenvironment of each feature and population.