Hwahyung Lee

TL;DR: The Ivy Glioblastoma Atlas is presented, an anatomically based transcriptional atlas of human gliOBlastoma that aligns individual histologic features with genomic alterations and gene expression patterns, thus assigning molecular information to the most important morphologic hallmarks of the tumor.

TL;DR: Using an integrated approach, this experimental paradigm provides a powerful new method for the identification of epigenetically silenced genes with potential function as tumor suppressors, biomarkers for disease diagnosis and detection, and therapeutically reversible modulators of critical regulatory pathways important in glioma pathogenesis.

TL;DR: A new classification scheme utilizing methylation data from across the entire MGMT promoter is proposed and an analysis based on this approach, which is called 3R classification, is predictive of progression-free survival.

TL;DR: W whole-genome microarray analysis yielded 714 up-regulated genes in immortalized medulloblastoma cell line D283 on treatment with histone deacetylase (HDAC) inhibitor trichostatin A (TSA).

TL;DR: This study highlights the prevalence of gene fusions as one of the major genomic abnormalities in GBM as a small subset of patients with fusions of receptor tyrosine kinases can benefit from existing FDA approved drugs and drugs available in various clinical trials.