M
Michael Menaker
Researcher at University of Virginia
Publications - 206
Citations - 26979
Michael Menaker is an academic researcher from University of Virginia. The author has contributed to research in topics: Circadian rhythm & Light effects on circadian rhythm. The author has an hindex of 77, co-authored 206 publications receiving 25480 citations. Previous affiliations of Michael Menaker include University of Oregon & Mitsubishi Tanabe Pharma.
Papers
More filters
Journal ArticleDOI
PERIOD2::LUCIFERASE real-time reporting of circadian dynamics reveals persistent circadian oscillations in mouse peripheral tissues
Seung Hee Yoo,Shin Yamazaki,Shin Yamazaki,Phillip L. Lowrey,Kazuhiro Shimomura,Caroline H. Ko,Caroline H. Ko,Ethan D. Buhr,Sandra M. Siepka,Hee Kyung Hong,Won Jun Oh,Ook Joon Yoo,Michael Menaker,Joseph S. Takahashi +13 more
TL;DR: It is demonstrated that peripheral tissues express self-sustained, rather than damped, circadian oscillations and the existence of organ-specific synchronizers of circadian rhythms at the cell and tissue level is suggested.
Journal ArticleDOI
Resetting Central and Peripheral Circadian Oscillators in Transgenic Rats
Shin Yamazaki,Rika Numano,Michikazu Abe,Akiko Hida,Ri Ichi Takahashi,Masatsugu Ueda,Gene D. Block,Yoshiyuki Sakaki,Michael Menaker,Hajime Tei +9 more
TL;DR: It is hypothesize that a self-sustained circadian pacemaker in the SCN entrains circadian oscillators in the periphery to maintain adaptive phase control, which is temporarily lost following large, abrupt shifts in the environmental light cycle.
Journal ArticleDOI
Transplanted suprachiasmatic nucleus determines circadian period
TL;DR: The pacemaker role of the suprachiasmatic nucleus in a mammalian circadian system was tested by neural transplantation by using a mutant strain of hamster that shows a short circadian period to restore circadian rhythms to arrhythmic animals whose own nucleus had been ablated.
Journal ArticleDOI
Entrainment of the Circadian Clock in the Liver by Feeding
TL;DR: It is demonstrated that feeding cycles can entrain the liver independently of the SCN and the light cycle, and the need to reexamine the mammalian circadian hierarchy is suggested, raising the possibility that peripheral circadian oscillators like those in the liver may be coupled to theSCN primarily through rhythmic behavior, such as feeding.
Journal ArticleDOI
Positional Syntenic Cloning and Functional Characterization of the Mammalian Circadian Mutation tau
Phillip L. Lowrey,Kazuhiro Shimomura,Marina P. Antoch,Shin Yamazaki,Peter D. Zemenides,Martin R. Ralph,Michael Menaker,Joseph S. Takahashi +7 more
TL;DR: The tau mutation is a semidominant autosomal allele that dramatically shortens period length of circadian rhythms in Syrian hamsters and the mechanism by which the mutation leads to the observed aberrant circadian phenotype in mutant animals is proposed.