M
Michael Mülleder
Researcher at Charité
Publications - 10
Citations - 641
Michael Mülleder is an academic researcher from Charité. The author has contributed to research in topics: Fermentation & Flux (metabolism). The author has an hindex of 5, co-authored 10 publications receiving 251 citations. Previous affiliations of Michael Mülleder include Francis Crick Institute.
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Journal ArticleDOI
Ultra-High-Throughput Clinical Proteomics Reveals Classifiers of COVID-19 Infection.
Christoph B. Messner,Vadim Demichev,Vadim Demichev,Daniel Wendisch,Laura Michalick,Matthew White,Anja Freiwald,Kathrin Textoris-Taube,Spyros I. Vernardis,Anna Sophia Egger,Marco Kreidl,Daniela Ludwig,Christiane Kilian,Federica Agostini,Aleksej Zelezniak,Aleksej Zelezniak,Charlotte Thibeault,Moritz Pfeiffer,Stefan Hippenstiel,Andreas C. Hocke,Christof von Kalle,Archie Campbell,Caroline Hayward,David J. Porteous,Riccardo E. Marioni,Claudia Langenberg,Claudia Langenberg,Kathryn S. Lilley,Wolfgang M. Kuebler,Michael Mülleder,Christian Drosten,Norbert Suttorp,Martin Witzenrath,Florian Kurth,Florian Kurth,Leif E. Sander,Markus Ralser,Markus Ralser +37 more
TL;DR: A platform for ultra-high throughput serum and plasma proteomics that builds on ISO13485 standardisation and high-flow liquid chromatography to facilitate implementation in clinical laboratories and identifies 27 potential biomarkers that are differentially expressed depending on the WHO severity grade of COVID-19.
Journal ArticleDOI
Virus-induced senescence is a driver and therapeutic target in COVID-19.
Soyoung Lee,Soyoung Lee,Yong Yu,Jakob Trimpert,Fahad Benthani,Mario Mairhofer,Paulina Richter-Pechanska,Emanuel Wyler,Dimitri Belenki,Dimitri Belenki,Sabine Kaltenbrunner,Maria Pammer,Lea Kausche,Theresa C. Firsching,Kristina Dietert,Michael Schotsaert,Carles Martínez-Romero,Gagandeep Singh,Séverine Kunz,Daniela Niemeyer,Riad Ghanem,Helmut J. F. Salzer,Christian Paar,Michael Mülleder,Melissa Uccellini,Melissa Uccellini,Edward Georg Michaelis,Amjad Khan,Andrea Lau,Martin Schönlein,Martin Schönlein,Anna Habringer,Josef Tomasits,Julia Adler,Susanne Kimeswenger,Achim D. Gruber,Wolfram Hoetzenecker,Herta Steinkellner,Bettina Purfürst,Reinhard Motz,Francesco Di Pierro,Bernd Lamprecht,Nikolaus Osterrieder,Nikolaus Osterrieder,Markus Landthaler,Christian Drosten,Adolfo García-Sastre,Rupert Langer,Markus Ralser,Markus Ralser,Roland Eils,Maurice Reimann,Dorothy N. Y. Fan,Clemens A. Schmitt +53 more
TL;DR: In this article, the authors show that SARS-CoV-2 evokes cellular senescence as a primary stress response in infected cells, and suggest that senolytic targeting of virus-infected cells is a treatment option against SARS and perhaps other viral infections.
Posted ContentDOI
High sensitivity dia-PASEF proteomics with DIA-NN and FragPipe
Demichev,Demichev,Demichev,Fengchao Yu,Guo Ci Teo,Szyrwiel L,Szyrwiel L,Rosenberger Ga,Jens Decker,Kaspar-Schoenefeld S,Kathryn S. Lilley,Michael Mülleder,Alexey I. Nesvizhskii,Markus Ralser,Markus Ralser +14 more
TL;DR: In this article, the authors demonstrate neural network-based processing of the ion mobility data, which they implement in the DIA-NN software suite, using spectral libraries generated with the MSFragger-based FragPipe computational platform.
Journal ArticleDOI
Pyruvate Kinase Variant of Fission Yeast Tunes Carbon Metabolism, Cell Regulation, Growth and Stress Resistance
Stephan Kamrad,Stephan Kamrad,Jan Grossbach,María Rodríguez-López,Michael Mülleder,Michael Mülleder,StJohn Townsend,StJohn Townsend,Valentina Cappelletti,Gorjan Stojanovski,Clara Correia-Melo,Paola Picotti,Andreas Beyer,Markus Ralser,Markus Ralser,Jürg Bähler +15 more
TL;DR: The genetic tuning of glycolytic flux may reflect an adaptive trade‐off in a species lacking pyruvate kinase isoforms, and low Pyk1 activity does not lead to a growth advantage but to stress tolerance.
Posted ContentDOI
A time-resolved proteomic and diagnostic map characterizes COVID-19 disease progression and predicts outcome
Vadim Demichev,Vadim Demichev,Vadim Demichev,Pinkus Tober-Lau,Tatiana Nazarenko,Charlotte Thibeault,Harry J. Whitwell,Oliver Lemke,Annika Röhl,Anja Freiwald,Lukasz Szyrwiel,Daniela Ludwig,Clara Correia-Melo,Elisa T Helbig,Paula Stubbemann,Nana-Maria Grüning,Oleg Blyuss,Oleg Blyuss,Spyros I. Vernardis,Matthew White,Christoph B. Messner,Christoph B. Messner,Michael Joannidis,Thomas Sonnweber,Sebastian J. Klein,Alex Pizzini,Yvonne Wohlfarter,Sabina Sahanic,Richard Hilbe,Benedikt Schaefer,Sonja Wagner,Mirja Mittermaier,Felix Machleidt,Carmen Garcia,Christoph Ruwwe-Glösenkamp,Tilman Lingscheid,Laure Bosquillon de Jarcy,Miriam Stegemann,Moritz Pfeiffer,Linda Jürgens,Sophy Denker,Daniel Zickler,Philipp Enghard,Aleksej Zelezniak,Aleksej Zelezniak,Archie Campbell,Caroline Hayward,David J. Porteous,Riccardo E. Marioni,Alexander Uhrig,Holger Müller-Redetzky,Heinz Zoller,Judith Löffler-Ragg,Markus A. Keller,Ivan Tancevski,John F. Timms,Alexey Zaikin,Stefan Hippenstiel,Michael Ramharter,Martin Witzenrath,Norbert Suttorp,Kathryn S. Lilley,Michael Mülleder,Leif E. Sander,Markus Ralser,Markus Ralser,Florian Kurth,Florian Kurth +67 more
TL;DR: This study provides a deep and time resolved molecular characterization of COVID-19 disease progression, and reports biomarkers for risk-adapted treatment strategies and molecular disease monitoring.