M
Michael T. Tetzlaff
Researcher at University of California, San Francisco
Publications - 17
Citations - 581
Michael T. Tetzlaff is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Melanoma & Neoadjuvant therapy. The author has an hindex of 7, co-authored 17 publications receiving 427 citations. Previous affiliations of Michael T. Tetzlaff include University of Texas Health Science Center at Houston & Cleveland Clinic.
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Journal ArticleDOI
Differential Expression of miRNAs in Papillary Thyroid Carcinoma Compared to Multinodular Goiter Using Formalin Fixed Paraffin Embedded Tissues
Michael T. Tetzlaff,Aihua Liu,Xiaowei Xu,Stephen R. Master,Don A. Baldwin,John W. Tobias,Virginia A. LiVolsi,Zubair W. Baloch +7 more
TL;DR: This work exploited the ability to procure sufficient miRNA from formalin-fixed paraffin-embedded (FFPE) tissue to describe a series of miRNAs whose expression is dysregulated in PTC compared to benign proliferative multinodular goiter (MNG), and suggested that FFPE tissues are suitable resources for miRNA expression analyses.
Journal ArticleDOI
Beyond BRAFV600: Clinical Mutation Panel Testing by Next-Generation Sequencing in Advanced Melanoma
Alan E. Siroy,Genevieve M. Boland,Denái R. Milton,Jason Roszik,Silva Frankian,Jared Malke,Lauren E. Haydu,Victor G. Prieto,Michael T. Tetzlaff,Doina Ivan,Wei Lien Wang,Carlos A. Torres-Cabala,Jonathan L. Curry,Sinchita Roy-Chowdhuri,Russell R. Broaddus,Asif Rashid,John Stewart,Jeffrey E. Gershenwald,Rodabe N. Amaria,Sapna P. Patel,Nicholas E. Papadopoulos,Agop Y. Bedikian,Wen-Jen Hwu,P. Hwu,Adi Diab,Scott E. Woodman,Kenneth Aldape,Rajyalakshmi Luthra,Keyur P. Patel,Kenna R. Shaw,Gordon B. Mills,John Mendelsohn,Funda Meric-Bernstam,Kevin B. Kim,Mark J. Routbort,Alexander J. Lazar,Michael A. Davies +36 more
TL;DR: In this paper, the results of clinical testing of 699 advanced melanoma patients using a pan-cancer next-generation sequencing (NGS) panel of hotspot regions in 46 genes were reviewed.
Journal ArticleDOI
Tumor-infiltrating mast cells are associated with resistance to anti-PD-1 therapy.
Rajasekharan Somasundaram,Thomas Connelly,Robin Choi,Hyeree Choi,Anastasia Samarkina,Ling Li,Elizabeth Gregorio,Yeqing Chen,Rohit Thakur,Mohamed Abdel-Mohsen,Marilda Beqiri,Meaghan Kiernan,Michela Perego,Fang Wang,Min Xiao,Patricia Brafford,Xue Yang,Xiaowei Xu,Anthony Secreto,Gwenn Danet-Desnoyers,Daniel Traum,Klaus H. Kaestner,Alexander C. Huang,Denitsa Hristova,Joshua Wang,Mizuho Fukunaga-Kalabis,Clemens Krepler,Fang Ping-Chen,Xiangyang Zhou,Alexis Gutierrez,Vito W. Rebecca,Prashanthi Vonteddu,Farokh Dotiwala,Shashi Bala,Sonali Majumdar,Harsh Dweep,Jayamanna Wickramasinghe,Andrew V. Kossenkov,Jorge Reyes-Arbujas,Kenisha Santiago,Tran Nguyen,Johannes Griss,Frederick Keeney,James Hayden,Brian J. Gavin,David B. Weiner,Luis J. Montaner,Qin Liu,Lukas Peiffer,Jürgen C. Becker,Elizabeth M. Burton,Michael A. Davies,Michael T. Tetzlaff,Karuppiah Muthumani,Jennifer A. Wargo,Dmitry I. Gabrilovich,Meenhard Herlyn +56 more
TL;DR: In this paper, a humanized (Hu)-mouse melanoma model was generated by injecting fetal liver-derived CD34+ cells and implanting autologous thymus in immune-deficient NOD-scid IL2Rγnull (NSG) mice.
Journal ArticleDOI
Comparison between melanoma gene expression score and fluorescence in situ hybridization for the classification of melanocytic lesions
Eugen C. Minca,Rami N. Al-Rohil,Min Wang,Paul W. Harms,Jennifer S. Ko,Angela M. B. Collie,Ivanka Kovalyshyn,Victor G. Prieto,Michael T. Tetzlaff,Steven D. Billings,Aleodor A. Andea +10 more
TL;DR: FISH and gene expression score are valuable ancillary tools, though both have limitations and return discordant results in a subset of cases, and follow-up studies are warranted to establish the accuracy of these tests for the classification of melanocytic lesions.
Systematic identification of signaling pathways with potential to confer anticancer drug resistance
Colin A. Martz,Kathleen Ottina,Katherine R. Singleton,J. Jasper,Suzanne E. Wardell,Ashley Peraza-Penton,Grace R. Anderson,Peter S. Winter,Holly M. Alley,Lawrence N. Kwong,Zachary A. Cooper,Michael T. Tetzlaff,Pei Ling Chen,Jeffrey C. Rathmell,Keith T. Flaherty,Jennifer A. Wargo,Donald P. McDonnell,Kris C. Wood,Timothy C. Wang,David M. Sabatini +19 more
TL;DR: Activation of the Notch1 pathway promoted acquired resistance to tamoxifen in serially passaged breast cancer xenografts in mice, and treating mice with a γ-secretase inhibitor to inhibit Notch signaling restored tamoxIFen sensitivity.