R
Rohit Thakur
Researcher at University of Texas MD Anderson Cancer Center
Publications - 12
Citations - 1342
Rohit Thakur is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Melanoma & Biology. The author has an hindex of 5, co-authored 10 publications receiving 611 citations. Previous affiliations of Rohit Thakur include University of Leeds & National Institutes of Health.
Papers
More filters
Journal ArticleDOI
B cells and tertiary lymphoid structures promote immunotherapy response
Beth A. Helmink,Sangeetha M. Reddy,Jianjun Gao,Shaojun Zhang,Rafet Basar,Rohit Thakur,Keren Yizhak,Moshe Sade-Feldman,Moshe Sade-Feldman,Jorge Blando,Guangchun Han,Vancheswaran Gopalakrishnan,Yuanxin Xi,Hao Zhao,Rodabe N. Amaria,Hussein Abdul-Hassan Tawbi,Alex P. Cogdill,Wenbin Liu,Valerie S. LeBleu,Fernanda G. Kugeratski,Sapna Pradyuman Patel,Michael A. Davies,Patrick Hwu,Jeffrey E. Lee,Jeffrey E. Gershenwald,Anthony Lucci,Reetakshi Arora,Scott E. Woodman,Emily Z. Keung,Pierre Olivier Gaudreau,Alexandre Reuben,Christine N. Spencer,Elizabeth M. Burton,Lauren E. Haydu,Alexander J. Lazar,Roberta Zapassodi,Courtney W. Hudgens,Deborah A. Ledesma,SuFey Ong,Michael Bailey,Sarah Warren,Disha Rao,Oscar Krijgsman,Elisa A. Rozeman,Daniel S. Peeper,Christian U. Blank,Ton N. Schumacher,Lisa H. Butterfield,Monika A. Zelazowska,Kevin M. McBride,Raghu Kalluri,James P. Allison,Florent Petitprez,Florent Petitprez,Wolf H. Fridman,Wolf H. Fridman,Catherine Sautès-Fridman,Catherine Sautès-Fridman,Nir Hacohen,Nir Hacohen,Katayoun Rezvani,Padmanee Sharma,Michael T. Tetzlaff,Linghua Wang,Jennifer A. Wargo +64 more
TL;DR: B cell markers were the most differentially expressed genes in the tumours of responders versus non-responders and insights are provided into the potential role of B cells and tertiary lymphoid structures in the response to ICB treatment, with implications for the development of biomarkers and therapeutic targets.
Journal ArticleDOI
Tumor-infiltrating mast cells are associated with resistance to anti-PD-1 therapy.
Rajasekharan Somasundaram,Thomas Connelly,Robin Choi,Hyeree Choi,Anastasia Samarkina,Ling Li,Elizabeth Gregorio,Yeqing Chen,Rohit Thakur,Mohamed Abdel-Mohsen,Marilda Beqiri,Meaghan Kiernan,Michela Perego,Fang Wang,Min Xiao,Patricia Brafford,Xue Yang,Xiaowei Xu,Anthony Secreto,Gwenn Danet-Desnoyers,Daniel Traum,Klaus H. Kaestner,Alexander C. Huang,Denitsa Hristova,Joshua Wang,Mizuho Fukunaga-Kalabis,Clemens Krepler,Fang Ping-Chen,Xiangyang Zhou,Alexis Gutierrez,Vito W. Rebecca,Prashanthi Vonteddu,Farokh Dotiwala,Shashi Bala,Sonali Majumdar,Harsh Dweep,Jayamanna Wickramasinghe,Andrew V. Kossenkov,Jorge Reyes-Arbujas,Kenisha Santiago,Tran Nguyen,Johannes Griss,Frederick Keeney,James Hayden,Brian J. Gavin,David B. Weiner,Luis J. Montaner,Qin Liu,Lukas Peiffer,Jürgen C. Becker,Elizabeth M. Burton,Michael A. Davies,Michael T. Tetzlaff,Karuppiah Muthumani,Jennifer A. Wargo,Dmitry I. Gabrilovich,Meenhard Herlyn +56 more
TL;DR: In this paper, a humanized (Hu)-mouse melanoma model was generated by injecting fetal liver-derived CD34+ cells and implanting autologous thymus in immune-deficient NOD-scid IL2Rγnull (NSG) mice.
Journal ArticleDOI
Transcriptomic Analysis Reveals Prognostic Molecular Signatures of Stage I Melanoma
Rohit Thakur,Rohit Thakur,Jonathan P. Laye,Martin Lauss,Joey Mark S. Diaz,Sally Jane O'Shea,Joanna Poźniak,Joanna Poźniak,Anastasia Filia,Mark Harland,Joanne Gascoyne,Juliette Randerson-Moor,May Chan,Tracey Mell,Göran Jönsson,D. Timothy Bishop,Julia Newton-Bishop,Jennifer H. Barrett,Jérémie Nsengimana +18 more
TL;DR: A transcriptomic signature of primary melanoma was identified with prognostic value, including in stage I melanoma and in patients undergoing immunotherapy, especially for AJCC stage I and stage II disease.
Journal ArticleDOI
Stroma remodeling and reduced cell division define durable response to PD-1 blockade in melanoma.
Elena Galvani,Piyushkumar A. Mundra,Sara Valpione,Pablo Garcia-Martinez,Matthew Smith,Jonathan Greenall,Rohit Thakur,Beth A. Helmink,Miles C. Andrews,Miles C. Andrews,Louis Boon,Christopher P. E. Chester,Gabriela Gremel,Kate Hogan,A. Mandal,Kang Zeng,Antonia Banyard,Garry Ashton,Martin G. Cook,Paul Lorigan,Jennifer A. Wargo,Nathalie Dhomen,Richard Marais +22 more
TL;DR: It is shown that stroma remodelling and reduced cell division are associated with durable response to anti-PD1 in a mouse model of melanoma and in ICB-treated patients.
A large Canadian cohort provides insights into the genetic architecture of human hair colour.
Frida Lona-Durazo,Marla Mendes,Marla Mendes,Rohit Thakur,Karen M. Funderburk,Tongwu Zhang,Michael A. Kovacs,Jiyeon Choi,Kevin M. Brown,Esteban J. Parra +9 more
TL;DR: Lona-Durazo et al. as discussed by the authors conducted GWAS meta-analyses of hair color in a Canadian cohort of 12,741 individuals of European ancestry and identified candidate causal variants in pigmentation loci associated with blonde, red and brown hair colour.