Michal Jarnik

TL;DR: At least one of the compensatory mechanisms preventing a more severe skin phenotype in newborn Lor−/− mice is an increase in the expression of other CE components, such as SPRRP2D and SPR RP2H, members of the family of “small proline rich proteins”, and repetin, a member of the “fused gene” subgroup of the S100 gene family.

TL;DR: The identification of a multisubunit complex named BORC that regulates lysosome positioning is reported, which comprises eight subunits that functions to recruit the small GTPase Arl8 and promotes the kinesin-dependent movement of lysOSomes toward the plus ends of microtubules in the peripheral cytoplasm.

TL;DR: The findings suggest that the ESCRT machinery required for the scission of HIV particles from infected cells is located within the core of the virus particle and not, as might have been expected based on previous work, on the cellular side of the membrane scission event involved in viral budding.

TL;DR: The requirement of Ama1p only for meiosis I and spore morphogenesis suggests a function for APC/C(Ama1) specifically adapted to germ cell development.

TL;DR: Overall, the findings reveal that a subset of procollagen molecules is directed toward lysosomal degradation through an autophagic pathway originating at ERESs, providing a mechanism to remove excess Procollagen from cells.