M
Michel Goedert
Researcher at Laboratory of Molecular Biology
Publications - 353
Citations - 72555
Michel Goedert is an academic researcher from Laboratory of Molecular Biology. The author has contributed to research in topics: Tau protein & Frontotemporal dementia and parkinsonism linked to chromosome 17. The author has an hindex of 125, co-authored 337 publications receiving 64671 citations. Previous affiliations of Michel Goedert include University of Pisa & Max Planck Society.
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Journal ArticleDOI
The abnormal phosphorylation of tau at ser396 in alzheimerʼs disease recapitulates phosphorylation during development and contributes to reduced microtubule binding
Journal ArticleDOI
Synthesis and Assessment of Novel Probes for Imaging Tau Pathology in Transgenic Mouse and Rat Models
Lindsay McMurray,Jennifer A. Macdonald,Nisha K. Ramakrishnan,Yanyan Zhao,David W. Williamson,Ole Tietz,Xiaoyun Zhou,Steven Kealey,Steven G. Fagan,Tomas Smolek,Veronika Cubinkova,Norbert Žilka,Maria Grazia Spillantini,Aviva M. Tolkovsky,Michel Goedert,Franklin I. Aigbirhio +15 more
TL;DR: In this article, a novel library of compounds based on the phenyl/pyridinylbutadienylbenzothiazoles/benzinothiazolium (PBB3) backbone was developed for PET imaging radiotracers that selectively bind to aggregated tau in fibril form.
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The comparative distribution of [Lys8-Asn9]-neurotensin8-13-like immunoreactivity in chicken and rat tissues.
TL;DR: The present results indicate that [Lys8-Asn9]-neurotensin8-13-like immunoreactivity is not present in rat tissues and that which was detected resulted from an extraction artefact.
Journal ArticleDOI
Cytosolic antibody receptor TRIM21 is required for effective tau immunotherapy in mouse models
Aamir S. Mukadam,Lauren V. C. Miller,Annabel E Smith,Marina Vaysburd,Siri Aastedatter Sakya,Sophie Sanford,Sophie Keeling,Benjamin J. Tuck,Taxiarchis Katsinelos,Sanne S Kaalund,Stian Foss,Keith Mayes,Kevin O’Connell,M. G. Wing,Claire Knox,Edward Avezov,James B. Rowe,Michel Goedert,Jan Terje Andersen,Leo C. James,William A. McEwan +20 more
TL;DR: In this article , the cytosolic Ab receptor and E3 ligase TRIM21 (T21) were used to protect against seeded aggregation of protein tau in a variety of cell and animal model systems.