M
Michel Goedert
Researcher at Laboratory of Molecular Biology
Publications - 353
Citations - 72555
Michel Goedert is an academic researcher from Laboratory of Molecular Biology. The author has contributed to research in topics: Tau protein & Frontotemporal dementia and parkinsonism linked to chromosome 17. The author has an hindex of 125, co-authored 337 publications receiving 64671 citations. Previous affiliations of Michel Goedert include University of Pisa & Max Planck Society.
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Journal ArticleDOI
Cerebrospinal fluid from Alzheimer’s disease patients promotes tau aggregation in transgenic mice
Zhiva Skachokova,Alfonso Martinisi,Martin Flach,Frederik Sprenger,Yvonne Naegelin,Viviane Steiner-Monard,Marc Sollberger,Marc Sollberger,Andreas U. Monsch,Michel Goedert,Markus Tolnay,David T. Winkler +11 more
TL;DR: It is demonstrated that biologically active tau seeds reach the CSF compartment in AD, the first evidence for in vivo prion-like properties of AD patients’ CSF, accelerating tau pathology in susceptible tau transgenic mice.
Journal ArticleDOI
Biochemical effects of nerve growth factor and its antibody on the vas defferens and the adrenal medulla.
TL;DR: This discrepancy might indicate that NSF is not an absolute prerequisite for the development and maintenance of function of these organs, although they do not respond by a selective increase in TH and DBH activities.
Book ChapterDOI
Tau gene mutations and tau pathology in frontotemporal dementia and parkinsonism linked to chromosome 17.
TL;DR: Frontotemporal dementia was first described by Arnold Pick in 18921 and in the 1960’s, so-called Pick bodies were shown to contain abnormal filaments, now known to be made of hyperphosphorylated microtubule-associated protein tau.
Journal ArticleDOI
Piericidin A aggravates Tau pathology in P301S transgenic mice.
Matthias Höllerhage,Roman Deck,Anderson de Andrade,Gesine Respondek,Hong Xu,Thomas W. Rösler,Mohamed Salama,Thomas Carlsson,Elizabeth Sumi Yamada,Seham A. Gad El Hak,Michel Goedert,Wolfgang H. Oertel,Günter U. Höglinger +12 more
TL;DR: Exposure to piericidin A aggravates the course of genetically determined tau pathology, providing experimental support for the concept of gene-environment interaction in the etiology of tauopathies.
Journal ArticleDOI
Changes in substance P concentrations after protein synthesis inhibition provide an index of substance P utilization.
TL;DR: In all but one brain region sampled, substance P-like immunoreactivity (SPLI) was unchanged 4 h after a dose of cycloheximide that produced a near-total inhibition of rat brain protein synthesis, suggesting that brain substance P (SP) utilization is slow under basal conditions.