M
Michel Goedert
Researcher at Laboratory of Molecular Biology
Publications - 353
Citations - 72555
Michel Goedert is an academic researcher from Laboratory of Molecular Biology. The author has contributed to research in topics: Tau protein & Frontotemporal dementia and parkinsonism linked to chromosome 17. The author has an hindex of 125, co-authored 337 publications receiving 64671 citations. Previous affiliations of Michel Goedert include University of Pisa & Max Planck Society.
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Journal ArticleDOI
Long-Term In Vivo Imaging of Fibrillar Tau in the Retina of P301S Transgenic Mice
Christian Schön,Nadine A. Hoffmann,Nadine A. Hoffmann,Simon M. Ochs,Steffen Burgold,Steffen Burgold,Severin Filser,Sonja Steinbach,Mathias W. Seeliger,Thomas Arzberger,Michel Goedert,Hans A. Kretzschmar,Boris Schmidt,Jochen Herms +13 more
TL;DR: The observations do not support the notion that Aβ or tau in the retina are of diagnostic value in Alzheimer's disease.
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Propagation of Tau aggregates
TL;DR: In mice, the intracerebral injection of Tau inclusions induced the ordered assembly of monomeric Tau, followed by its spreading to distant brain regions, and short fibrils constituted the major species of seed-competent Tau.
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Tau protein is phosphorylated by cyclic AMP-dependent protein kinase and calcium/calmodulin-dependent protein kinase II within its microtubule-binding domains at Ser-262 and Ser-356.
TL;DR: Evidence is presented that phosphorylation of both these sites occurs in cultured nerve cells under certain conditions, indicating their potential physiological relevance.
Journal ArticleDOI
Transmission and spreading of tauopathies in transgenic mouse brain
Florence Clavaguera,Bernardino Ghetti,Gabriel Schweighauser,Hiroyasu Akatsu,Jürgen Hench,Markus Tolnay,Michel Goedert +6 more
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Tau mutations in frontotemporal dementia FTDP-17 and their relevance for Alzheimer's disease.
TL;DR: Assembly of tau into filaments may be the gain of toxic function that is believed to underlie the demise of affected brain cells, and is the defining neuropathological characteristic of frontotemporal dementias, such as Pick's disease.