M
Michel Goedert
Researcher at Laboratory of Molecular Biology
Publications - 353
Citations - 72555
Michel Goedert is an academic researcher from Laboratory of Molecular Biology. The author has contributed to research in topics: Tau protein & Frontotemporal dementia and parkinsonism linked to chromosome 17. The author has an hindex of 125, co-authored 337 publications receiving 64671 citations. Previous affiliations of Michel Goedert include University of Pisa & Max Planck Society.
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Journal ArticleDOI
Stimulation of autophagy is neuroprotective in a mouse model of human tauopathy.
TL;DR: A role for autophagy stimulation in the degradation of MAPT aggregates is supported and new perspectives for the investigation of autophileagy as a pathological mechanism involved in neurodegenerative diseases are opened.
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Familial multiple-system tauopathy with presenile dementia is localized to chromosome 17.
Jill R. Murrell,Daniel L. Koller,Tatiana Foroud,Michel Goedert,Maria Grazia Spillantini,Howard J. Edenberg,Martin R. Farlow,Bernardino Ghetti +7 more
TL;DR: Neuropathologic studies of nine affected individuals showed neuronal loss in several areas of the CNS, as well as argentophilic tau-immunopositive inclusions in neurons and in oligodendroglia.
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Parkinson's Disease – the Debate on the Clinical Phenomenology, Aetiology, Pathology and Pathogenesis
Peter Jenner,Huw R. Morris,Trevor W. Robbins,Michel Goedert,John Hardy,Yoav Ben-Shlomo,Paul Bolam,David J. Burn,John V. Hindle,David J. Brooks +9 more
TL;DR: The conclusion reached is that in the future, further diagnostic categories will need to be recognized and the heterogeneity that exists within PD itself from a clinical, pathological and genetic per-spective must be recognized.
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Isoform-specific interactions of apolipoprotein E with the microtubule-associated protein MAP2c: implications for Alzheimer's disease
David Huang,Michel Goedert,R. Jakes,Karl H. Weisgraber,Craig C. Garner,Ann M. Saunders,Margaret A. Pericak-Vance,Donald E. Schmechel,Allen D. Roses,Warren J. Strittmatter +9 more
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A novel tau mutation, S320F, causes a tauopathy with inclusions similar to those in Pick's disease.
Sonia M. Rosso,Esther van Herpen,Wout H. Deelen,Wouter Kamphorst,Lies-Anne Severijnen,Rob Willemsen,Rivka Ravid,Martinus F. Niermeijer,Dennis Dooijes,Michael J. Smith,Michel Goedert,Peter Heutink,John C. van Swieten +12 more
TL;DR: A novel missense mutation, S320F, in the tau gene in a family with presenile dementia is described, the first mutation to be described in exon 11 of tau.