M
Michel van Geel
Researcher at Roswell Park Cancer Institute
Publications - 4
Citations - 290
Michel van Geel is an academic researcher from Roswell Park Cancer Institute. The author has contributed to research in topics: Facioscapulohumeral muscular dystrophy & Pseudogene. The author has an hindex of 4, co-authored 4 publications receiving 279 citations.
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Journal ArticleDOI
Genomic Analysis of Human Chromosome 10q and 4q Telomeres Suggests a Common Origin
Michel van Geel,Morag C. Dickson,Amy Beck,Daniel J. Bolland,Daniel J. Bolland,Rune R. Frants,Silvère M. van der Maarel,Pieter J. de Jong,Jane E. Hewitt,Jane E. Hewitt +9 more
TL;DR: It is shown here that the 4q homology on chromosome 10 is not confined to the 3.3-kb repeats but extends both proximally and distally to include the telomere, which may represent a relatively common subtelomeric domain.
Journal ArticleDOI
Complete allele information in the diagnosis of facioscapulohumeral muscular dystrophy by triple DNA analysis.
Richard J.L.F. Lemmers,Peggy de Kievit,Michel van Geel,Michiel J.R. van der Wielen,Egbert Bakker,George W. Padberg,Rune R. Frants,Silvère M. van der Maarel +7 more
TL;DR: A triple analysis with EcoRI, EcoRI/BlnI, and XapI unequivocally allows characterization of each of the four alleles, whether homogeneous or hybrid, in situations of suspected facioscapulohumeral muscular dystrophy with nonstandard allele configurations.
Journal ArticleDOI
A cascade of complex subtelomeric duplications during the evolution of the hominoid and Old World monkey genomes.
Michel van Geel,Evan E. Eichler,Amy Beck,Zhihong Shan,Thomas Haaf,Silvère M. van der Maarel,Rune R. Frants,Pieter J. de Jong +7 more
TL;DR: It is proposed that, in a chimpanzee-human common ancestor, one of the paralogous copies assumed the original function, whereas the ancestral copy acquired mutations and eventually became silenced.
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Recent amplification of the human FRG1 gene during primate evolution.
TL;DR: It is proposed that an ancestral duplication of distal 4q included FRG1, and this telomeric region then underwent further amplification and dispersion events in the great ape lineage, with copies ofFRG1 and the 3.3-kb repeats being localized in heterochromatic regions.