C
Caren Norden
Researcher at Max Planck Society
Publications - 66
Citations - 3596
Caren Norden is an academic researcher from Max Planck Society. The author has contributed to research in topics: Retina & Medicine. The author has an hindex of 25, co-authored 57 publications receiving 2636 citations. Previous affiliations of Caren Norden include ETH Zurich & Instituto Gulbenkian de Ciência.
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Journal ArticleDOI
Content-aware image restoration: pushing the limits of fluorescence microscopy.
Martin Weigert,Uwe Schmidt,Tobias Boothe,Andreas Müller,Alexandr Dibrov,Akanksha Jain,Benjamin Wilhelm,Deborah Schmidt,Coleman Broaddus,Siân Culley,Siân Culley,Mauricio Rocha-Martins,Fabián Segovia-Miranda,Caren Norden,Ricardo Henriques,Ricardo Henriques,Marino Zerial,Michele Solimena,Jochen C. Rink,Pavel Tomancak,Loic Royer,Florian Jug,Eugene W. Myers,Eugene W. Myers +23 more
TL;DR: This work shows how content-aware image restoration based on deep learning extends the range of biological phenomena observable by microscopy by bypassing the trade-offs between imaging speed, resolution, and maximal light exposure that limit fluorescence imaging to enable discovery.
Journal ArticleDOI
The NoCut Pathway Links Completion of Cytokinesis to Spindle Midzone Function to Prevent Chromosome Breakage
TL;DR: It is proposed that NoCut monitors clearance of chromatin from the midzone to ensure that cytokinesis completes only after all chromosomes have migrated to the poles.
Journal ArticleDOI
Phototoxicity in live fluorescence microscopy, and how to avoid it.
TL;DR: It is argued that phototoxicity needs increased attention from researchers when designing experiments, and when evaluating research findings, because there are often subtler consequences of illumination that are imperceptible when only the morphology of samples is examined.
Posted ContentDOI
Content-Aware Image Restoration: Pushing the Limits of Fluorescence Microscopy
Martin Weigert,Uwe Schmidt,Tobias Boothe,Andreas Müller,Alexandr Dibrov,Akanksha Jain,Benjamin Wilhelm,Deborah Schmidt,Coleman Broaddus,Siân Culley,Mauricio Rocha-Martins,Fabián Segovia-Miranda,Caren Norden,Ricardo Henriques,Marino Zerial,Michele Solimena,Jochen C. Rink,Pavel Tomancak,Loic Royer,Florian Jug,Eugene W. Myers,Eugene W. Myers +21 more
TL;DR: This work shows how deep learning enables biological observations beyond the physical limitations of microscopes, and illustrates how microscopy images can be restored even if 60-fold fewer photons are used during acquisition.
Journal ArticleDOI
Actomyosin is the main driver of interkinetic nuclear migration in the retina.
TL;DR: Using time-lapse confocal microscopy to observe nuclear movements in zebrafish retinal neuroepithelial cells, it is shown that, except for brief apical nuclear translocations preceding mitosis, IKNM is stochastic rather than smooth and directed.