M
Martin Weigert
Researcher at École Polytechnique Fédérale de Lausanne
Publications - 190
Citations - 19783
Martin Weigert is an academic researcher from École Polytechnique Fédérale de Lausanne. The author has contributed to research in topics: Antibody & Antigen. The author has an hindex of 63, co-authored 179 publications receiving 17123 citations. Previous affiliations of Martin Weigert include University of Chicago & Drexel University.
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Journal ArticleDOI
A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation
Avinash Patel,Hyun O. Lee,Louise Jawerth,Shovamayee Maharana,Marcus Jahnel,Marco Y. Hein,Stoyno S. Stoynov,Julia Mahamid,Shambaditya Saha,Titus M. Franzmann,Andrej Pozniakovski,Ina Poser,Nicola Maghelli,Loic Royer,Martin Weigert,Eugene W. Myers,Stephan W. Grill,David N. Drechsel,Anthony A. Hyman,Simon Alberti +19 more
TL;DR: It is proposed that liquid-like compartments carry the trade-off between functionality and risk of aggregation and that aberrant phase transitions within liquid- like compartments lie at the heart of ALS and, presumably, other age-related diseases.
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Receptor editing: an approach by autoreactive B cells to escape tolerance.
TL;DR: In this paper, the fate of anti-DNA antibody-bearing B cells in normal mice was determined by generating transgenic mice bearing the heavy (H) and light (L) chain genes of a well-characterized anti-double-stranded DNA antibody.
Journal ArticleDOI
The role of clonal selection and somatic mutation in autoimmunity.
Mark J. Shlomchik,Ann Marshak-Rothstein,Claudia B. Wolfowicz,Thomas L. Rothstein,Martin Weigert +4 more
TL;DR: The genetic features and clonal composition of spontaneously derived immunoglobulin G (IG) antiself-IgG (rheumatoid factor (RF) autoantibodies derived from the autoimmune MRL/lpr mouse strain are inconsistent with both the predictions of this model and the actual outcome of experimental polyclonal activation.
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Content-aware image restoration: pushing the limits of fluorescence microscopy.
Martin Weigert,Uwe Schmidt,Tobias Boothe,Andreas Müller,Alexandr Dibrov,Akanksha Jain,Benjamin Wilhelm,Deborah Schmidt,Coleman Broaddus,Siân Culley,Siân Culley,Mauricio Rocha-Martins,Fabián Segovia-Miranda,Caren Norden,Ricardo Henriques,Ricardo Henriques,Marino Zerial,Michele Solimena,Jochen C. Rink,Pavel Tomancak,Loic Royer,Florian Jug,Eugene W. Myers,Eugene W. Myers +23 more
TL;DR: This work shows how content-aware image restoration based on deep learning extends the range of biological phenomena observable by microscopy by bypassing the trade-offs between imaging speed, resolution, and maximal light exposure that limit fluorescence imaging to enable discovery.
Journal ArticleDOI
Anti-DNA antibodies from autoimmune mice arise by clonal expansion and somatic mutation.
Mark J. Shlomchik,Mary Ann Mascelli,H. Shan,Marko Z. Radic,David S. Pisetsky,Ann Marshak-Rothstein,Martin Weigert +6 more
TL;DR: Analysis of monoclonal anti- DNA autoantibodies derived from unmanipulated spleen cells of the autoimmune MRL/lpr mouse strain shows that anti-DNAs, like rheumatoid factors, are the result of specific antigen-driven stimulation.