M
Michelle M. A. Fernando
Researcher at King's College London
Publications - 16
Citations - 2680
Michelle M. A. Fernando is an academic researcher from King's College London. The author has contributed to research in topics: Linkage disequilibrium & Human leukocyte antigen. The author has an hindex of 10, co-authored 14 publications receiving 2463 citations. Previous affiliations of Michelle M. A. Fernando include Hammersmith Hospital & Imperial College London.
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Journal ArticleDOI
Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci.
John B. Harley,John B. Harley,John B. Harley,Marta E. Alarcón-Riquelme,Lindsey A. Criswell,Chaim O. Jacob,Robert P. Kimberly,Kathy L. Moser,Kathy L. Moser,Betty P. Tsao,Timothy J. Vyse,Carl D. Langefeld,Swapan K. Nath,Joel M. Guthridge,Beth L. Cobb,Daniel B. Mirel,Miranda C. Marion,Adrienne H. Williams,Jasmin Divers,Wei Wang,Summer G. Frank,Bahram Namjou,Stacey Gabriel,Annette Lee,Peter K. Gregersen,Timothy W. Behrens,Timothy W. Behrens,Kimberly E. Taylor,Michelle M. A. Fernando,Raphael Zidovetzki,Patrick M. Gaffney,Patrick M. Gaffney,Jeffrey C. Edberg,John D. Rioux,Joshua O. Ojwang,Judith A. James,Joan T. Merrill,Gary S. Gilkeson,Michael F. Seldin,Hong Yin,Emily C. Baechler,Quan Zhen Li,Edward K. Wakeland,Gail R. Bruner,Kenneth M. Kaufman,Kenneth M. Kaufman,Jennifer A. Kelly +46 more
TL;DR: The results show that numerous genes, some with known immune-related functions, predispose to SLE, and evidence of association with replication is found at FCGR2A, PTPN22 and STAT4, regions previously associated with SLE and other autoimmune diseases.
Journal ArticleDOI
Defining the Role of the MHC in Autoimmunity: A Review and Pooled Analysis
Michelle M. A. Fernando,Christine Stevens,Emily C. Walsh,Philip L. De Jager,Philip L. De Jager,Philip L. De Jager,Philippe Goyette,Robert M. Plenge,Robert M. Plenge,Timothy J. Vyse,John D. Rioux,John D. Rioux +11 more
TL;DR: A number of interesting commonalities and differences across diseases that implicate both general and disease-specific pathogenetic mechanisms in autoimmunity are found.
Journal ArticleDOI
Mapping of multiple susceptibility variants within the MHC region for 7 immune-mediated diseases
John D. Rioux,John D. Rioux,Philippe Goyette,Philippe Goyette,Timothy J. Vyse,Lennart Hammarström,Michelle M. A. Fernando,Todd Green,Philip L. De Jager,Philip L. De Jager,Sylvain Foisy,Sylvain Foisy,Joanne Wang,Paul I.W. de Bakker,Stephen Leslie,Gilean McVean,Leonid Padyukov,Lars Alfredsson,Vito Annese,David A. Hafler,Qiang Pan-Hammarström,Ritva Matell,Stephen Sawcer,Alastair Compston,Bruce A.C. Cree,Daniel B. Mirel,Mark J. Daly,Timothy W. Behrens,Lars Klareskog,Peter K. Gregersen,Jorge R. Oksenberg,Stephen L. Hauser +31 more
TL;DR: The data demonstrate that MHC associations with autoimmune diseases result from complex, multilocus effects that span the entire region.
Journal ArticleDOI
Identification of two independent risk factors for lupus within the MHC in United Kingdom families
Michelle M. A. Fernando,Christine Stevens,Pardis C. Sabeti,Emily C. Walsh,A.J. McWhinnie,Anila Shah,Todd Green,John D. Rioux,John D. Rioux,Timothy J. Vyse +9 more
TL;DR: A family-based approach is used to map association signals across the MHC class II and class III regions in a cohort of 314 complete United Kingdom Caucasian SLE trios by typing tagging SNPs together with classical typing of the HLA-DRB1 locus and demonstrates the presence of two distinct and independent association signals.
Journal ArticleDOI
Unraveling multiple MHC gene associations with systemic lupus erythematosus: model choice indicates a role for HLA alleles and non-HLA genes in Europeans.
David L. Morris,Kimberly E. Taylor,Michelle M. A. Fernando,Joanne Nititham,Marta E. Alarcón-Riquelme,Marta E. Alarcón-Riquelme,Lisa F. Barcellos,Timothy W. Behrens,Chris Cotsapas,Patrick M. Gaffney,Robert R. Graham,Bernardo A. Pons-Estel,Peter K. Gregersen,John B. Harley,Stephen L. Hauser,Geoffrey Hom,Carl D. Langefeld,Janelle A. Noble,John D. Rioux,Michael F. Seldin,Lindsey A. Criswell,Timothy J. Vyse +21 more
TL;DR: A meta-analysis of the major-histocompatibility-complex region in systemic lupus erythematosus (SLE) to determine the association with both SNPs and classical human-leukocyte-antigen (HLA) alleles found a model that was an overwhelmingly better fit to the data than one identified by simple stepwise regression.