Michiel Matthijs

TL;DR: DiatomCyc, a detailed pathway/genome database of P. tricornutum, contains 286 pathways with 1719 metabolic reactions and 1613 assigned enzymes, and will feed metabolic engineering strategies for the industrial valorization of diatoms.

TL;DR: It is demonstrated that diatom-specific cyclin 2 (dsCYC2) in Phaeodactylum tricornutum displays a transcriptional peak within 15 min after light exposure, long before the onset of cell division.

TL;DR: A peculiar, chimeric organization of the diatom sterol biosynthesis pathway is revealed, which possesses features of both plant and fungal pathways and underscores the metabolic plasticity of diatoms and offers important insights for the engineering of di atoms for sustainable production of biofuels and high-value chemicals.

TL;DR: This is the most extensive pathway engineering undertaken in a diatom and the first time that a sapogenin has been artificially produced in a microalga, demonstrating the feasibility of the photo‐bio‐production of more complex high‐value, metabolites in microalgae.

TL;DR: The data indicate that the TCA cycle is a tightly regulated and important hub for carbon reallocation in the diatom cell during nutrient starvation and that bZIP14 is a conserved regulator of this cycle.