M
Miguel Alaminos
Researcher at University of Granada
Publications - 178
Citations - 6054
Miguel Alaminos is an academic researcher from University of Granada. The author has contributed to research in topics: Tissue engineering & Mesenchymal stem cell. The author has an hindex of 39, co-authored 163 publications receiving 5157 citations. Previous affiliations of Miguel Alaminos include Catalan Institution for Research and Advanced Studies & Spanish National Research Council.
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Journal ArticleDOI
Rb inactivation promotes genomic instability by uncoupling cell cycle progression from mitotic control
Eva Hernando,Zaher Nahlé,Zaher Nahlé,Gloria Juan,Elena Diaz-Rodriguez,Miguel Alaminos,Miguel Alaminos,Michael T. Hemann,Loren S. Michel,Vivek Mittal,William L. Gerald,Robert Benezra,Scott W. Lowe,Carlos Cordon-Cardo +13 more
TL;DR: It is demonstrated how chromosome instability can arise as a by-product of defects in cell cycle control that compromise the accuracy of mitosis, and a new model is suggested to explain the frequent appearance of aneuploidy in human cancer.
Journal ArticleDOI
A truncating mutation of HDAC2 in human cancers confers resistance to histone deacetylase inhibition
Santiago Ropero,Mario F. Fraga,Esteban Ballestar,Richard Hamelin,Hiroyuki Yamamoto,Manuel Boix-Chornet,Rosalia Caballero,Miguel Alaminos,Fernando Setien,Maria F. Paz,Michel Herranz,José Palacios,Diego Arango,Torben F. Ørntoft,Lauri A. Aaltonen,Simó Schwartz,Manel Esteller +16 more
TL;DR: The identified truncating mutations in one of the primary human histone deacetylases, HDAC2, are identified in sporadic carcinomas with microsatellite instability and in tumors arising in individuals with hereditary nonpolyposis colorectal cancer syndrome and support the use ofHDAC2 mutational status in future pharmacogenetic treatment of these individuals.
Journal ArticleDOI
Construction of a complete rabbit cornea substitute using a fibrin-agarose scaffold.
Miguel Alaminos,María del Carmen Sánchez-Quevedo,José Ignacio Muñoz-Ávila,Daniel Serrano,Santiago Medialdea,Ignacio Carreras,António Campos +6 more
TL;DR: These findings suggest that development of a full-thickness rabbit cornea model is possible in the laboratory and may open new avenues for research.
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Epigenetic inactivation of the Sotos overgrowth syndrome gene histone methyltransferase NSD1 in human neuroblastoma and glioma
María Berdasco,Santiago Ropero,Fernando Setien,Mario F. Fraga,Pablo Lapunzina,Régine Losson,Miguel Alaminos,Nai-Kong V. Cheung,Nazneen Rahman,Manel Esteller +9 more
TL;DR: It is reported that NSD1 function is abrogated in human neuroblastoma and glioma cells by transcriptional silencing associated with CpG island-promoter hypermethylation and it is demonstrated that the epigenetic inactivation of N SD1 in transformed cells leads to the specifically diminished methylation of the histone lysine residues H4-K20 and H3-K36.
Journal ArticleDOI
A microarray-based DNA methylation study of glioblastoma multiforme
Ramon Martinez,José I. Martín-Subero,Veit Rohde,Matthias Kirsch,Miguel Alaminos,Agustín F. Fernández,Santiago Ropero,Gabriele Schackert,Manel Esteller +8 more
TL;DR: The DNA methylation level of 1,505 CpG dinucleotides (807 genes) in 87 consecutive GBMs using universal BeadArrays is quantified and the group of genes hypermethylated in GBM was highly enriched (41%, P).