Mikael Ebbo

TL;DR: Results suggest that blockade of the C5a–C5aR1 axis could be used to limit the infiltration of myeloid cells in damaged organs and prevent the excessive lung inflammation and endothelialitis that are associated with acute respiratory distress syndrome in patients with COVID-19.

TL;DR: Using high‐throughput single‐cell RNA‐seq, Crinier et al. provide conserved tissue‐specific gene signatures of NK cells from spleen and blood and identified two major NK cell subsets transcriptionally similar across organs and species.

TL;DR: The roles of ILCs in inflammatory diseases are detailed; this work covers type 2 inflammatory diseases (such as asthma, chronic rhinosinusitis and atopic dermatitis), as well as inflammatory bowel diseases, psoriasis and other systemic or organ-specific inflammatory and autoimmune diseases.

TL;DR: The authors investigated the presence of ILCs in a cohort of patients with severe combined immunodeficiency (SCID) and found that ILC subsets were absent in patients with SCID who had mutation of the gene encoding the common γ-chain cytokine receptor subunit IL-2Rγ or the tyrosine kinase JAK3.

TL;DR: In this paper, the clinical, laboratory, and histologic characteristics of 25 patients from a French nationwide cohort were reported, which strongly suggest the implication of a T-cell dependent B-cell polyclonal activation in IgG4-related systemic disease, probably under the control of T helper follicular cells.