Sabrina Carpentier

TL;DR: Results suggest that blockade of the C5a–C5aR1 axis could be used to limit the infiltration of myeloid cells in damaged organs and prevent the excessive lung inflammation and endothelialitis that are associated with acute respiratory distress syndrome in patients with COVID-19.

TL;DR: The data show that interplay between intestinal ILC3 cells and adaptive lymphocytes results in robust complementary failsafe mechanisms that ensure gut homeostasis, and the transcriptional signature associated with the transcription factor T-bet–dependent differentiation of NCR− ILC2 cells into NCR+ I LC3 cells is identified.

TL;DR: An overview of what is known about NK tumor infiltration and surveillance and about the mechanisms by which NK cells become dysfunctional is provided and the functions of tumor-infiltrating NK cells may be impaired.

TL;DR: These results support the evaluation of avdoralimab to block C5a-C5aR1 axis as a mean of limiting myeloid cell infiltration in damaged organs and preventing the excessive lung inflammation and endothelialitis associated with ARDS in COVID-19 patients.

TL;DR: It is shown that thymic XCR1(+) DCs undergo a high rate of maturation, accompanied by profound gene-expression changes that are essential for central tolerance and also happen in germ-free mice, arguing against the commonly held view that tolerogenicDCs undergo incomplete maturation.