L
Lionel Spinelli
Researcher at Aix-Marseille University
Publications - 50
Citations - 1402
Lionel Spinelli is an academic researcher from Aix-Marseille University. The author has contributed to research in topics: Biology & Immunology. The author has an hindex of 18, co-authored 39 publications receiving 985 citations. Previous affiliations of Lionel Spinelli include University of Provence & French Institute of Health and Medical Research.
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Journal ArticleDOI
High-Dimensional Single-Cell Analysis Identifies Organ-Specific Signatures and Conserved NK Cell Subsets in Humans and Mice
Adeline Crinier,Pierre Milpied,Bertrand Escalière,Christelle Piperoglou,Justine Galluso,Anaïs Balsamo,Lionel Spinelli,Inaki Cervera-Marzal,Mikael Ebbo,Mathilde J. H. Girard-Madoux,Sébastien Jaeger,Emilie Bollon,Sami Hamed,Jean Hardwigsen,Sophie Ugolini,Frédéric Vély,Emilie Narni-Mancinelli,Eric Vivier +17 more
TL;DR: Using high‐throughput single‐cell RNA‐seq, Crinier et al. provide conserved tissue‐specific gene signatures of NK cells from spleen and blood and identified two major NK cell subsets transcriptionally similar across organs and species.
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Human germinal center transcriptional programs are de-synchronized in B cell lymphoma.
Pierre Milpied,Inaki Cervera-Marzal,Marie-Laure Mollichella,Bruno Tesson,Gabriel Brisou,Alexandra Traverse-Glehen,Gilles Salles,Lionel Spinelli,Bertrand Nadel +8 more
TL;DR: The data show that lymphoma B cells are not blocked in a GC B cell state but might adopt new dynamic modes of functional diversity, which opens the possibility of novel definitions of lymphoma identity.
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Extreme multifunctional proteins identified from a human protein interaction network.
Charles E. Chapple,Benoît Robisson,Benoît Robisson,Lionel Spinelli,Celine Guien,Celine Guien,Emmanuelle Becker,Emmanuelle Becker,Emmanuelle Becker,Christine Brun +9 more
TL;DR: This work proposes the first method for the identification of ‘extreme multifunctional' proteins from an interactome as a first step to characterize moonlighting proteins, and shows that the candidates form a distinct sub-group of proteins, characterized by specific features, which form a signature of extreme multifunctionality.
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Tyrosine phosphorylation of RNA polymerase II CTD is associated with antisense promoter transcription and active enhancers in mammalian cells
Nicolas Descostes,Martin Heidemann,Lionel Spinelli,Roland Schüller,Muhammad Ahmad Maqbool,Romain Fenouil,Romain Fenouil,Romain Fenouil,Frederic Koch,Charlène Innocenti,Charlène Innocenti,Charlène Innocenti,Marta Gut,Ivo Gut,Dirk Eick,Jean-Christophe Andrau +15 more
TL;DR: The results suggest that Tyr1P has evolved specialized and essential functions in higher eukaryotes associated with antisense promoter and enhancer transcription, and Pol II stability.
Journal ArticleDOI
Protein complex scaffolding predicted as a prevalent function of long non-coding RNAs.
Diogo M Ribeiro,Andreas Zanzoni,Andrea Cipriano,Riccardo Delli Ponti,Lionel Spinelli,Monica Ballarino,Irene Bozzoni,Gian Gaetano Tartaglia,Gian Gaetano Tartaglia,Christine Brun,Christine Brun +10 more
TL;DR: This work proposes the first computational approach aimed at predicting scaffolding lncRNAs at large scale and suggests for the first time that RNA-mediated scaffolding of protein complexes and modules may be a common mechanism in human cells.