M
Miki Fujimura
Researcher at Tohoku University
Publications - 338
Citations - 13058
Miki Fujimura is an academic researcher from Tohoku University. The author has contributed to research in topics: Moyamoya disease & Cerebral blood flow. The author has an hindex of 50, co-authored 289 publications receiving 11341 citations. Previous affiliations of Miki Fujimura include Stanford University.
Papers
More filters
Journal ArticleDOI
Aquaporin-4 deletion in mice reduces brain edema after acute water intoxication and ischemic stroke.
Geoffrey T. Manley,Miki Fujimura,Tonghui Ma,Nobuo Noshita,Ferda Filiz,Andrew W. Bollen,Pak H. Chan,Alan S. Verkman +7 more
TL;DR: It is shown that mice deficient in aquaporin-4 (AQP4), a glial membrane water channel, have much better survival than wild-type mice in a model of brain edema caused by acute water intoxication, and suggested that AQP4 inhibition may provide a new therapeutic option for reducingbrain edema in a wide variety of cerebral disorders.
Journal ArticleDOI
A genome-wide association study identifies RNF213 as the first Moyamoya disease gene
Fumiaki Kamada,Yoko Aoki,Ayumi Narisawa,Yu Abe,Shoko Komatsuzaki,Atsuo Kikuchi,Junko Kanno,Tetsuya Niihori,Masao Ono,Naoto Ishii,Yuji Owada,Miki Fujimura,Yoichi Mashimo,Yoichi Suzuki,Akira Hata,Shigeru Tsuchiya,Teiji Tominaga,Yoichi Matsubara,Shigeo Kure +18 more
TL;DR: Results indicate that RNF213 is the first identified susceptibility gene for MMD, and it is confirmed that mature lymphocytes express higher levels of Rnf213 mRNA than their immature counterparts.
Journal ArticleDOI
Effects of Extracranial–Intracranial Bypass for Patients With Hemorrhagic Moyamoya Disease: Results of the Japan Adult Moyamoya Trial
Susumu Miyamoto,Takashi Yoshimoto,Nobuo Hashimoto,Yasushi Okada,Ichiro Tsuji,Teiji Tominaga,Jyoji Nakagawara,Jun C. Takahashi,Keisuke Yamada,Yasutake Tomata,Tsuguya Fukui,Yasuo Fukuuchi,Takashi Ohmoto,Yasuo Kuwabara,Izumi Nagata,Junichi Ono,Toshio Machida,Ryuji Sakakibara,Kanji Yamane,Shinji Okita,Toru Iwama,Yasuhiko Kaku,Nobuhito Saito,Hidenao Fukuyama,Kiyohiro Houkin,Satoshi Kuroda,Ichiro Yabe,Fumio Moriwaka,Akira Ogawa,Kuniaki Ogasawara,Kenji Yoshida,Kiyotaka Fujii,Masaru Yamada,Kimitoshi Sato,Tsugio Akutsu,Sen Yamagata,Shigekazu Takeuchi,Kentaro Hayashi,Nobutaka Horie,Kazuo Yamada,Toshiaki Osato,Toshiichi Watanabe,Kaori Honjo,Kazuya Sako,Hiroyuki Nakase,Shoichiro Kawaguchi,Fumihiko Nisimura,Junichi Yamao,Hiroaki Naritomi,Tooru Inoue,Hiroshi Abe,Akifumi Suzuki,Tatsuya Ishikawa,Yoshinori Akiyama,Toshihiko Suenaga,Miki Fujimura,Shinji Nagahiro,Masaaki Uno,Kyoko Nishi,Junichiro Satomi,Yoshikazu Okada,Akiji Kawashima,Kohji Yamaguchi,Yukiko Tsutsumi +63 more
TL;DR: Although statistically marginal, Kaplan–Meier analysis revealed the significant difference between surgical and nonsurgical group, suggesting the preventive effect of direct bypass against rebleeding.
Journal ArticleDOI
Early appearance of activated matrix metalloproteinase-9 after focal cerebral ischemia in mice: a possible role in blood-brain barrier dysfunction.
Yvan Gasche,Miki Fujimura,Yuiko Morita-Fujimura,Jean-Christophe Copin,Makoto Kawase,Justin Massengale,Pak H. Chan +6 more
TL;DR: The appearance of activated MMP-9 after 4 hours of ischemia in correlation with BBB permeability alterations suggests that M MP-9 may play an active role in early vasogenic edema development after stroke.
Journal ArticleDOI
Prevalence and Clinicoepidemiological Features of Moyamoya Disease in Japan. Findings From a Nationwide Epidemiological Survey
Shinichi Kuriyama,Yasuko Kusaka,Miki Fujimura,Kenji Wakai,Akiko Tamakoshi,Shuji Hashimoto,Ichiro Tsuji,Yutaka Inaba,Takashi Yoshimoto +8 more
TL;DR: The estimated prevalence of moyamoya disease in Japan has almost doubled during the recent decade and the clinicoepidemiological features of the patients in the present study were almost similar to those obtained in previous ones.