M
Min Y. Cho
Researcher at University of California, San Francisco
Publications - 7
Citations - 2171
Min Y. Cho is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Rigosertib & CRISPR. The author has an hindex of 6, co-authored 7 publications receiving 1603 citations. Previous affiliations of Min Y. Cho include Howard Hughes Medical Institute.
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Journal ArticleDOI
A Multiplexed Single-Cell CRISPR Screening Platform Enables Systematic Dissection of the Unfolded Protein Response.
Britt Adamson,Thomas M. Norman,Marco Jost,Min Y. Cho,James K. Nuñez,Yuwen Chen,Jacqueline E. Villalta,Luke A. Gilbert,Max A. Horlbeck,Marco Y. Hein,Ryan A. Pak,Andrew N. Gray,Carol A. Gross,Atray Dixit,Oren Parnas,Aviv Regev,Jonathan S. Weissman +16 more
TL;DR: Perturb-seq as mentioned in this paper combines droplet-based single-cell RNA-seq with a strategy for barcoding CRISPR-mediated perturbations, allowing many perturbation to be profiled in pooled format.
A Multiplexed Single-Cell CRISPR Screening Platform Enables Systematic Dissection of the Unfolded Protein Response
Britt Adamson,Thomas M. Norman,Marco Jost,Min Y. Cho,James K. Nuñez,Yuwen Chen,Jacqueline E. Villalta,Luke A. Gilbert,Max A. Horlbeck,Marco Y. Hein,Ryan A. Pak,Andrew N. Gray,Carol A. Gross,Oren Parnas,Jonathan S. Weissman,Atray Dixit,Aviv Regev +16 more
TL;DR: Insight is provided into how the three sensors of ER homeostasis monitor distinct types of stress and the ability of Perturb-seq to dissect complex cellular responses are highlighted.
Journal ArticleDOI
CRISPRi-based genome-scale identification of functional long noncoding RNA loci in human cells
S. John Liu,Max A. Horlbeck,Seung Woo Cho,Harjus Birk,Martina Malatesta,Daniel He,Frank J. Attenello,Jacqueline E. Villalta,Min Y. Cho,Yuwen Chen,Mohammad A. Mandegar,Michael P. Olvera,Luke A. Gilbert,Bruce R. Conklin,Howard Y. Chang,Jonathan S. Weissman,Daniel A. Lim,Daniel A. Lim +17 more
TL;DR: A large-scale CRISPR-based screen to assess the function of ∼17,000 lncRNAs in seven different human cell lines showed that lncRNA function is highly cell type–specific, a finding that has important implications for their involvement in organismal development and disease.
Journal ArticleDOI
Combined CRISPRi/a-Based Chemical Genetic Screens Reveal that Rigosertib Is a Microtubule-Destabilizing Agent.
Marco Jost,Yuwen Chen,Luke A. Gilbert,Max A. Horlbeck,Lenno Krenning,Grégory Menchon,Ankit Rai,Min Y. Cho,Jacob J. Stern,Andrea E. Prota,Martin Kampmann,Anna Akhmanova,Michel O. Steinmetz,Marvin E. Tanenbaum,Jonathan S. Weissman +14 more
TL;DR: A two-tiered CRISPR-mediated chemical-genetic strategy for target identification: combined genome-wide knockdown and overexpression screening as well as focused, comparative chemical- genetic profiling are presented.
Journal ArticleDOI
Paradoxical resistance of multiple myeloma to proteasome inhibitors by decreased levels of 19S proteasomal subunits
Diego Acosta-Alvear,Diego Acosta-Alvear,Min Y. Cho,Min Y. Cho,Thomas Wild,Tonia J Buchholz,Alana G. Lerner,Olga Simakova,Jamie Hahn,Neha Korde,Ola Landgren,Irina Maric,Chunaram Choudhary,Peter Walter,Peter Walter,Jonathan S. Weissman,Jonathan S. Weissman,Martin Kampmann,Martin Kampmann +18 more
TL;DR: Using a next-generation shRNA platform, it is found that proteostasis factors, including chaperones and stress-response regulators, controlled the response to carfilzomib, suggesting that an understanding of network rewiring can inform development of new combination therapies to overcome drug resistance.