M
Mirco Fanelli
Researcher at University of Urbino
Publications - 65
Citations - 3668
Mirco Fanelli is an academic researcher from University of Urbino. The author has contributed to research in topics: Acute promyelocytic leukemia & Epigenetics. The author has an hindex of 25, co-authored 59 publications receiving 3364 citations. Previous affiliations of Mirco Fanelli include European Institute of Oncology & University of Camerino.
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Journal ArticleDOI
Methyltransferase Recruitment and DNA Hypermethylation of Target Promoters by an Oncogenic Transcription Factor
Luciano Di Croce,Veronica A. Raker,Massimo Corsaro,Francesco Fazi,Mirco Fanelli,Mirco Fanelli,Mario Faretta,François Fuks,Francesco Lo Coco,Tony Kouzarides,Clara Nervi,Saverio Minucci,Pier Giuseppe Pelicci +12 more
TL;DR: It is reported here that the leukemia-promoting PML-RAR fusion protein induces gene hypermethylation and silencing by recruiting DNA methyltransferases to target promoters and that hyper methylation contributes to its leukemogenic potential.
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Aberrant Recruitment of the Nuclear Receptor Corepressor-Histone Deacetylase Complex by the Acute Myeloid Leukemia Fusion Partner ETO
Vania Gelmetti,Jinsong Zhang,Mirco Fanelli,Saverio Minucci,Pier Giuseppe Pelicci,Mitchell A. Lazar +5 more
TL;DR: It is reported that ETO, which is fused to the acute myelogenous leukemia 1 (AML1) transcription factor in t(8;21) AML, interacts via its zinc finger region with a conserved domain of the corepressors N-CoR and SMRT and recruits HDAC in vivo.
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Arsenic Trioxide as an Inducer of Apoptosis and Loss of PML/RARα Protein in Acute Promyelocytic Leukemia Cells
Wenlin Shao,Mirco Fanelli,Felicetto Ferrara,R. Riccioni,Angelika Rosenauer,Kelly Davison,William W. Lamph,Samuel Waxman,P. G. Pelicci,F Lo Coco,Giuseppe Avvisati,Ugo Testa,Cesare Peschle,Carlo Gambacorti-Passerini,Clara Nervi,Wilson H. Miller +15 more
TL;DR: The molecular basis of these differences in the effects of As2O3 and retinoic acid may guide the clinical use of arsenic compounds and provide insights into the management of leukemias that do not respond to retinic acid.
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Inhibition of the ABL kinase activity blocks the proliferation of BCR/ABL+ leukemic cells and induces apoptosis
Carlo Gambacorti-Passerini,Philipp le Coutre,Luca Mologni,Mirco Fanelli,Carla Bertazzoli,Edoardo Marchesi,Massimo Di Nicola,Andrea Biondi,Gian Marco Corneo,Daniela Belotti,Enrico Pogliani,Nicholas B. Lydon +11 more
TL;DR: The activity of CGP57148B on the spontaneous proliferation of both fresh and cultured, leukemic and normal, BCR/ABL positive and negative cells, and its mechanism of action are investigated to support the use of this molecule in initial clinical studies.
Journal ArticleDOI
Caspases Mediate Retinoic Acid–Induced Degradation of the Acute Promyelocytic Leukemia PML/RARα Fusion Protein
Clara Nervi,Fabiana Fosca Ferrara,Mirco Fanelli,Maria Rita Rippo,Barbara Tomassini,Pier Francesco Ferrucci,Martin Ruthardt,Vania Gelmetti,Carlo Gambacorti-Passerini,Daniela Diverio,Francesco Grignani,Pier Giuseppe Pelicci,Roberto Testi +12 more
TL;DR: Results indicate that PML/RARalpha is directly involved in conferring RA sensitivity of APL cells and that the RA-induced reassembly of PML NBs is the consequence of the disappearance of PMl/Raralpha.