M
Monther Abu-Remaileh
Researcher at Massachusetts Institute of Technology
Publications - 51
Citations - 6611
Monther Abu-Remaileh is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 22, co-authored 34 publications receiving 4469 citations. Previous affiliations of Monther Abu-Remaileh include Hebrew University of Jerusalem & Stanford University.
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Journal ArticleDOI
An essential role of the mitochondrial electron transport chain in cell proliferation is to enable aspartate synthesis
Kıvanç Birsoy,Timothy C. Wang,Walter W. Chen,Elizaveta Freinkman,Monther Abu-Remaileh,David M. Sabatini +5 more
TL;DR: A CRISPR-based genetic screen was used to identify genes whose loss sensitizes human cells to phenformin, a complex I inhibitor, and yielded GOT1, the cytosolic aspartate aminotransferase, loss of which kills cells upon ETC inhibition.
An Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis
Kıvanç Birsoy,Timothy C. Wang,Walter W. Chen,Elizaveta Freinkman,Monther Abu-Remaileh,David M. Sabatini +5 more
TL;DR: In this article, the authors used a CRISPR-based genetic screen to identify genes whose loss sensitizes human cells to phenformin, a complex I inhibitor, and yielded GOT1, the cytosolic aspartate aminotransferase, loss of which kills cells upon ETC inhibition.
Journal ArticleDOI
High-fat diet enhances stemness and tumorigenicity of intestinal progenitors
Semir Beyaz,Semir Beyaz,Miyeko D. Mana,Jatin Roper,Jatin Roper,Dmitriy Kedrin,Dmitriy Kedrin,Assieh Saadatpour,Sue Jean Hong,Khristian E. Bauer-Rowe,Michael E. Xifaras,Adam Akkad,Erika Arias,Luca Pinello,Yarden Katz,Shweta Shinagare,Monther Abu-Remaileh,Maria M. Mihaylova,Dudley W. Lamming,Rizkullah Dogum,Guoji Guo,George W. Bell,Martin K. Selig,G. Petur Nielsen,Nitin K. Gupta,Cristina R. Ferrone,Vikram Deshpande,Guo-Cheng Yuan,Stuart H. Orkin,David M. Sabatini,David M. Sabatini,Ömer H. Yilmaz,Ömer H. Yilmaz,Ömer H. Yilmaz +33 more
TL;DR: It is shown that high-fat diet (HFD)-induced obesity augments the numbers and function of Lgr5+ intestinal stem cells of the mammalian intestine and highlights how diet-modulated PPAR-δ activation alters not only the function of intestinal stem and progenitor cells, but also their capacity to initiate tumours.
Journal ArticleDOI
De novo DNA methylation promoted by G9a prevents reprogramming of embryonically silenced genes
Silvina Epsztejn-Litman,Nirit Feldman,Monther Abu-Remaileh,Yoel Shufaro,Ariela Gerson,Jun Ueda,Rachel Deplus,François Fuks,Yoichi Shinkai,Howard Cedar,Yehudit Bergman +10 more
TL;DR: Embryonic pluripotency-determining gene Oct3/4 may operate as a master regulator that inactivates numerous early-embryonic genes by bringing about heterochromatinization of methylated histone H3K9 and de novo DNA methylation.
Journal ArticleDOI
Lysosomal metabolomics reveals V-ATPase- and mTOR-dependent regulation of amino acid efflux from lysosomes
Monther Abu-Remaileh,Gregory A. Wyant,Choah Kim,Nouf N. Laqtom,Maria Abbasi,Sze Ham Chan,Elizaveta Freinkman,David M. Sabatini +7 more
TL;DR: In this article, a method for the rapid isolation of mammalian lysosomes and use it to quantitatively profile lyssomal metabolites under various cell states was described. And the results reveal the dynamic nature of LSA metabolites and that V-ATPase-and mTOR-dependent mechanisms exist for controlling LSA amino acid efflux.