M
Montserrat Camps
Researcher at Merck Serono
Publications - 73
Citations - 8670
Montserrat Camps is an academic researcher from Merck Serono. The author has contributed to research in topics: Mitogen-activated protein kinase & MAP2K7. The author has an hindex of 37, co-authored 73 publications receiving 8263 citations. Previous affiliations of Montserrat Camps include University of Barcelona & Merck KGaA.
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Journal ArticleDOI
Isoform-Specific Functions of Phosphoinositide 3-Kinases: p110δ but Not p110γ Promotes Optimal Allergic Responses In Vivo
Khaled Ali,Montserrat Camps,Wayne Pearce,Hong Ji,Thomas Rückle,Nicolas Kuehn,Christian Pasquali,Christian Chabert,Christian Rommel,Bart Vanhaesebroeck +9 more
TL;DR: It is confirmed that both PI3K isoforms play an important role in FcεRI-activated mast cell degranulation in vitro, but only p110δ was found to be required for optimal IgE/Ag-dependent hypersensitivity responses in mice.
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Design and synthesis of the first generation of novel potent, selective, and in vivo active (benzothiazol-2-yl)acetonitrile inhibitors of the c-Jun N-terminal kinase.
Pascale Gaillard,Isabelle Jeanclaude-Etter,Vittoria Ardissone,Steve Arkinstall,Yves Cambet,Montserrat Camps,Christian Chabert,Dennis Church,Rocco Cirillo,Denise Gretener,Serge Halazy,Anthony Nichols,Cedric Szyndralewiez,Pierre-Alain Vitte,Jean-Pierre Gotteland +14 more
TL;DR: The in vitro and in vivo anti-inflammatory potential of this new JNK inhibitor was investigated and found to demonstrate efficacy per oral route in an experimental model of rheumatoid arthritis (RA).
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Inactivation of PI3Kgamma and PI3Kdelta distorts T-cell development and causes multiple organ inflammation.
Hong Ji,Felix Rintelen,Caroline Waltzinger,Dominique Bertschy Meier,Antonio Bilancio,Wayne Pearce,Emilio Hirsch,Matthias P. Wymann,Thomas Rückle,Montserrat Camps,Bart Vanhaesebroeck,Klaus Okkenhaug,Christian Rommel +12 more
TL;DR: It is demonstrated that in mature T cells, p110delta, but not p110gamma, controls Th1 and Th2 cytokine secretion, and the pathology in the p110gammadelta-deficient mice is likely to be secondary to a developmental block in the thymus that leads to lymphopenia-associated inflammatory responses.
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Dopamine receptors in human brain: autoradiographic distribution of D1 and D2 sites in Parkinson syndrome of different etiology.
TL;DR: The distribution and density of dopamine D1 and D2 receptors were examined by autoradiography in postmortem brain tissue from patients with pathological diagnosis of Parkinson's disease, status lacunaris, clinical parkinsonism without neuropathological lesions and in age-matched controls.
Journal ArticleDOI
BMP2 induction of actin cytoskeleton reorganization and cell migration requires PI3-kinase and Cdc42 activity.
Cristina Gamell,Nelson Osses,Nelson Osses,Ramon Bartrons,Thomas Rückle,Montserrat Camps,Jose Luis Rosa,Francesc Ventura +7 more
TL;DR: Findings suggest that Cdc42 and PI3K signals emanating from BMP receptors are involved in specific regulation of actin assembly and cell migration.