Murray J. Cairns

TL;DR: Evidence is found to suggest that cAMP signalling may be partially involved in regulating the anti-inflammatory response of SSRIs, which could suggest that antidepressants may owe at least some of their therapeutic effectiveness to their anti- inflammatory properties.

TL;DR: In this article , the authors explored shared genetic architecture and evidence for causal relationships between a panel of 50 biochemical traits and measures of cortical thickness and surface area, and found strong evidence suggesting CRP and vitamin D exert causal effects on region-specific cortical thickness, with univariable and multivariable Mendelian randomization further supporting a negative causal relationship between serum CRP levels and thickness of the lingual region.

TL;DR: The construction and application of a random small RNA expression library is reported on, which identifies a range of small RNA-encoding gene inserts that overcome resistance to 5-fluorouracil or tumour necrosis factor alpha- induced cell death in colorectal cancer cells.

TL;DR: The sequence specificity of the "10-23" RNA-cleaving DNA enzyme can be utilized to discriminate between subtle differences in nucleic acid sequence to examine the HPV status of genomic DNA derived from Caski cells, which are known to be positive for HPV16.

TL;DR: In this article , the authors designed a custom sequencing panel of 161 genes selected based on the current knowledge of SCZ genetics and sequenced a new cohort of 11,580 SCZ cases and 10,555 controls of diverse ancestries.