Murray J. Cairns

TL;DR: In this paper, the authors apply a novel statistical algorithm called Covariate-Modulated Mixture Modeling (CM3), which incorporates auxiliary information (heterozygosity, total linkage disequilibrium, genomic annotations, pleiotropy) for each single nucleotide polymorphism (SNP) to enable more accurate estimation of replication probabilities, conditional on the observed test statistic (z-score) of the SNP.

TL;DR: A significant body of evidence in the literature now supports dysregulation of the retinoid system as being involved in the aetiology of schizophrenia, which includes mechanistic insights from large-scale genomic, transcriptomic and, proteomic studies, which implicate disruption of disparate aspects ofretinoid biology such as transport, metabolism, and signalling.

TL;DR: The biological saliency of PES profiles were observed directly through their impact on gene expression in a subset of the cohort with matched transcriptomic data, supporting the assertion that this gene-set orientated approach could integrate an individual’s common variant risk to inform personalised interventions, including drug repositioning, for complex disorders such as schizophrenia.

TL;DR: The present study confirmed that Arc messenger RNA was significantly decreased in the DS, but importantly, it was restricted to the dorsomedial (DMS) and not dorsolateral striatum (DLS) of addiction-vulnerable animals, and found that miR-212 expression was significantly reduced in the DMS but not DLS of Addiction-v vulnerable animals.

TL;DR: A role for circRNAs in the modification of gene regulation associated with neuronal activity is supported, suggesting a regulatory axis of circRNA–miRNA–mRNA is involved in the cellular response to neural activity.