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Murray J. Cairns

Researcher at University of Newcastle

Publications -  201
Citations -  14007

Murray J. Cairns is an academic researcher from University of Newcastle. The author has contributed to research in topics: microRNA & Gene. The author has an hindex of 45, co-authored 175 publications receiving 10172 citations. Previous affiliations of Murray J. Cairns include Harvard University & Johnson & Johnson.

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Increased power by harmonizing structural MRI site differences with the ComBat batch adjustment method in ENIGMA.

Joaquim Radua, +133 more
- 01 Sep 2020 - 
TL;DR: Whether the batch adjustment method, ComBat, can further reduce site-related heterogeneity and thus increase statistical power and recommend applying the ComBat function to attenuate potential effects of site in ENIGMA projects and other multi-site structural imaging work.
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Down-regulation of miR-17 family expression in response to retinoic acid induced neuronal differentiation.

TL;DR: Significantly, many of the target responses predicted by changes in miRNA expression were supported by the observed changes in gene expression, suggesting that the miR-17 family have an integral role in fine-tuning the pathways involved in the regulation of neuronal differentiation.
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Alterations in miRNA processing and expression in pleomorphic adenomas of the salivary gland

TL;DR: Changes in the miRNA milieu in pleomorphic adenoma, the most common salivary gland tumour, are demonstrated with an up regulation of both miRNAs genes and an upregulation of the mi RNA processing machinery, suggesting potential underlying mechanisms for the development of these benign tumours.
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MicroRNA: Small RNA mediators of the brains genomic response to environmental stress.

TL;DR: It is asserted that miRNA hold a significant position at the molecular crossroads between neural development and adaptations to environmental stress and stress- induced alterations in miRNA expression can regulate the stress response via modulation of the immune system.
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Super-enhancers in transcriptional regulation and genome organization.

TL;DR: A multi-stage transition model is proposed to explain the evolutionary pressure driving the development of super-enhancers in complex organisms, and the potential for involvement in tumorigenesis is highlighted.