Murray J. Cairns

TL;DR: It is demonstrated that these miRNAs modulate T cell activation genes in a knock-in and knock-down T cell model and also up-regulated in MS whole blood mRNA, suggesting these mi RNAs or their analogues may provide useful targets for new therapeutic approaches.

TL;DR: These findings further support a role for miRNA as neural plasticity regulators, as they are compartmentalized in neurons and undergo activity-associated redistribution or release into the extracellular matrix.

TL;DR: Investigation of the miRNA expression profile of peripheral blood mononuclear cells from 112 patients with schizophrenia and 76 non-psychiatric controls revealed a pattern of differentially expressed miRNA in PBMCs that may be indicative of significant underlying genetic or epigenetic alteration associated with schizophrenia.

TL;DR: Mounting evidence that mature miRNA levels are altered in both the cerebral cortex and peripheral blood mononuclear cells (PBMCs) in schizophrenia is examined and compelling evidence that the underlying miRNA biogenesis machinery and miRNA genes themselves are subject to disease-associated genetic mutation and epigenetic influence is examined.

TL;DR: A review of what is known about how microglia transform themselves during development, under physiological conditions in response to changes in neuronal activity, and under pathological circumstances examines a variety of models proposed to account for microglial transformation.