M
Murray J. Cairns
Researcher at University of Newcastle
Publications - 201
Citations - 14007
Murray J. Cairns is an academic researcher from University of Newcastle. The author has contributed to research in topics: microRNA & Gene. The author has an hindex of 45, co-authored 175 publications receiving 10172 citations. Previous affiliations of Murray J. Cairns include Harvard University & Johnson & Johnson.
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Journal ArticleDOI
The maternal immune activation model uncovers a role for the Arx gene in GABAergic dysfunction in schizophrenia
Jay P. Nakamura,Anna Schroeder,Matthew R. Hudson,Nigel C. Jones,Brendan Gillespie,Xin Du,Michael Notaras,Vaidy Swaminathan,William R. Reay,Joshua R. Atkins,Melissa J. Green,Vaughan J. Carr,Murray J. Cairns,Suresh Sundram,Rachel Anne Hill,Rachel Anne Hill +15 more
TL;DR: It is shown the Arx gene, critical to healthy neurodevelopment of PV interneurons, is reduced in the forebrain of MIA exposed mice, and that the ARX gene may play a role in the prenatal origins of schizophrenia pathophysiology.
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Antipsychotic Drug-Associated gene-miRNA Interaction in T-lymphocytes
TL;DR: Functional analysis of APD-associated differential expression revealed changes in genes related to oxidative stress, metabolic disease and surprisingly also implicated pathways and biological processes associated with neurological disease consistent with current understanding of the activity of APDs.
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Inhibition of extracellular matrix mediated TGF-β signalling suppresses endometrial cancer metastasis.
Subhransu S. Sahoo,Min Yuan Quah,Sarah Nielsen,Joshua R. Atkins,Gough G. Au,Murray J. Cairns,Pravin Nahar,Janine M. Lombard,Pradeep S. Tanwar +8 more
TL;DR: Key insights are provided into the role of ECM-derived TGF-β signalling to promote endometrial cancer metastasis and offer an avenue for therapeutic targeting of microenvironment derived signals along with tumour cells.
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MicroRNA-16 Is Down-Regulated in Mutated FLT3 Expressing Murine Myeloid FDC-P1 Cells and Interacts with Pim-1
TL;DR: MiR-16 was found to be one of most significantly down-regulated miRNAs in FLT3/ITD expressing cells and was up-regulated upon FLT 3 inhibition, and Pim-1 reporter gene expression was shown to be suppressed, suggesting that miR- 16 is acting as a tumour suppressor gene inFLT3 /ITD-mediated leukemic transformation.
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Ontogeny of small RNA in the regulation of mammalian brain development
Sharon L. Hollins,Belinda J. Goldie,Adam P. Carroll,Elizabeth A. Mason,Frederick R. Walker,Darryl W. Eyles,Darryl W. Eyles,Murray J. Cairns +7 more
TL;DR: The findings suggest that miRNA have significant implications for the development of neural structure and support important mechanisms that if disrupted, may contribute to or drive neurodevelopmental disorders.