M
Murray J. Cairns
Researcher at University of Newcastle
Publications - 201
Citations - 14007
Murray J. Cairns is an academic researcher from University of Newcastle. The author has contributed to research in topics: microRNA & Gene. The author has an hindex of 45, co-authored 175 publications receiving 10172 citations. Previous affiliations of Murray J. Cairns include Harvard University & Johnson & Johnson.
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Patent
Zymogenic nucleic acid detection methods and related kits
TL;DR: In this paper, a method for detecting and quantitatively determining a target nucleic acid sequence in a sample, which comprises contacting the sample with a primer and a zymogene which encodes, but which itself is the anti-sense sequence of, a catalytic nucleic acids sequence, is presented.
Journal ArticleDOI
Temporally specific miRNA expression patterns in the dorsal and ventral striatum of addiction-prone rats
Rikki K. Quinn,Morgan H. James,Morgan H. James,Guy E. Hawkins,Amanda L. Brown,Andrew Heathcote,Doug W. Smith,Murray J. Cairns,Christopher V. Dayas +8 more
TL;DR: Increased dysregulation of miRNA expression in NAcSh and DLS at late stages of the addiction cycle may underlie habitual drug seeking, and may therefore aid in the identification of targets designed to treat addiction.
Journal ArticleDOI
Interaction Testing and Polygenic Risk Scoring to Estimate the Association of Common Genetic Variants With Treatment Resistance in Schizophrenia
Antonio F. Pardiñas,Sophie Smart,Isabella Willcocks,Peter Holmans,Charlotte Dennison,Amy Lynham,Sophie E. Legge,Bernhard T. Baune,Tim B. Bigdeli,Murray J. Cairns,Aiden Corvin,Ayman H. Fanous,Josef Frank,Brian Kelly,Andrew McQuillin,Ingrid Melle,Preben Bo Mortensen,Bryan J. Mowry,Carlos N. Pato,Sathish Periyasamy,Marcella Rietschel,Dan Rujescu,Carmen Simonsen,David St Clair,Paul A. Tooney,Jing Qin Wu,Ole A. Andreassen,Kaarina Kowalec,Patrick F. Sullivan,Robin M. Murray,Michael John Owen,James H. MacCabe,Michael Conlon O'Donovan,James T.R. Walters,Olesya Ajnakina,Luis Alameda,Thomas R. E. Barnes,Domenico Berardi,Elena Bonora,Sara Camporesi,Martine Cleusix,Philippe Conus,Benedicto Crespo-Facorro,Giuseppe D’Andrea,Arsime Demjaha,Kim Q. Do,Gillian A. Doody,Chin B. Eap,Aziz Ferchiou,Marta Di Forti,L. Guidi,Lina Homman,Raoul Jenni,Eileen M. Joyce,L Kassoumeri,Ines Khadimallah,O. Lastrina,Roberto Muratori,Handan Noyan,F. Anthony O'Neill,Baptiste Pignon,Romeo Restellini,Jean Romain Richard,Franck Schürhoff,Filip Spaniel,Andrei Szöke,Ilaria Tarricone,Andrea Tortelli,Alp Üçok,Javier Vázquez-Bourgon +69 more
TL;DR: Findings of this study based on common genetic variants indicate that TRS is heritable with a modest but significant single-nucleotide variation–based heritability.
Journal ArticleDOI
Altered neural signaling and immune pathways in peripheral blood mononuclear cells of schizophrenia patients with cognitive impairment: A transcriptome analysis
Jing Qin Wu,Melissa J. Green,Erin Gardiner,Paul A. Tooney,Rodney J. Scott,Vaughan J. Carr,Murray J. Cairns +6 more
TL;DR: The WNT pathway plays a role in both the development/function of the central nervous system and peripheral tissues, therefore its alteration in PBMCs may be indicative of an important genomic axis relevant to cognition in the neuropathology of schizophrenia.
Journal ArticleDOI
Polygenic disruption of retinoid signalling in schizophrenia and a severe cognitive deficit subtype.
William R. Reay,Joshua R. Atkins,Yann Quidé,Yann Quidé,Vaughan J. Carr,Vaughan J. Carr,Vaughan J. Carr,Melissa J. Green,Melissa J. Green,Murray J. Cairns +9 more
TL;DR: The results suggest that genomic variation may disrupt retinoid signalling in schizophrenia, with particular significance for cases with severe cognitive impairment.