M
Myles Lewis
Researcher at Queen Mary University of London
Publications - 100
Citations - 2718
Myles Lewis is an academic researcher from Queen Mary University of London. The author has contributed to research in topics: Medicine & Rheumatoid arthritis. The author has an hindex of 21, co-authored 71 publications receiving 1615 citations. Previous affiliations of Myles Lewis include Royal London Hospital & St Thomas' Hospital.
Papers
More filters
Journal ArticleDOI
Lactate Buildup at the Site of Chronic Inflammation Promotes Disease by Inducing CD4+ T Cell Metabolic Rewiring.
Valentina Pucino,Valentina Pucino,Michelangelo Certo,Michelangelo Certo,Vinay Bulusu,Danilo Cucchi,Katriona Goldmann,Elena Pontarini,Robert Haas,Joanne Smith,Sarah E. Headland,K. Blighe,Massimiliano Ruscica,Frances Humby,Myles Lewis,Jurre J. Kamphorst,Michele Bombardieri,Costantino Pitzalis,Claudio Mauro +18 more
TL;DR: It is proposed that lactate/SLC5A12-induced metabolic reprogramming is a distinctive feature of lymphoid synovitis in rheumatoid arthritis patients and a potential therapeutic target in chronic inflammatory disorders.
Journal ArticleDOI
Immunoglobulin M Is Required for Protection Against Atherosclerosis in Low-Density Lipoprotein Receptor–Deficient Mice
Myles Lewis,Talat H. Malik,Michael R. Ehrenstein,Joseph J. Boyle,Marina Botto,Dorian O. Haskard +5 more
TL;DR: This study provides direct evidence that IgM antibodies play a central role in protection against atherosclerosis, and the mechanism appears to be at least partly independent of classical pathway complement activation by C1q.
Journal ArticleDOI
Distinct synovial tissue macrophage subsets regulate inflammation and remission in rheumatoid arthritis.
Stefano Alivernini,Lucy MacDonald,Aziza Elmesmari,Samuel Finlay,Barbara Tolusso,Maria Rita Gigante,Luca Petricca,Clara Di Mario,Laura Bui,Simone Perniola,Moustafa Attar,Marco Gessi,Anna Laura Fedele,Sabarinadh Chilaka,Domenico Somma,Stephen N. Sansom,Andrew Filer,Andrew Filer,Charles McSharry,Neal L. Millar,Kristina Kirschner,Alessandra Nerviani,Myles Lewis,Costantino Pitzalis,Andrew R. Clark,Gianfranco Ferraccioli,Irina A. Udalova,Christopher D. Buckley,Elisa Gremese,Elisa Gremese,Iain B. McInnes,Thomas D. Otto,Mariola Kurowska-Stolarska +32 more
TL;DR: Multiple subpopulations of synovial tissue macrophages with varied transcriptional, phenotypic and functional features may contribute to disease flare and tissue repair in patients with active rheumatoid arthritis and patients in clinical remission.
Journal ArticleDOI
Molecular Portraits of Early Rheumatoid Arthritis Identify Clinical and Treatment Response Phenotypes
Myles Lewis,Michael R. Barnes,Michael R. Barnes,K. Blighe,Katriona Goldmann,Sharmila Rana,Jason A. Hackney,Nandhini Ramamoorthi,Christopher R. John,David Watson,David Watson,David Watson,Sarah K. Kummerfeld,Rebecca Hands,Sudeh Riahi,Vidalba Rocher-Ros,Felice Rivellese,Frances Humby,Stephen Kelly,Michele Bombardieri,Nora Ng,M DiCicco,Désirée van der Heijde,Robert Landewé,Annette H M van der Helm-van Mil,Alberto Cauli,Iain B. McInnes,Christopher D. Buckley,Christopher D. Buckley,Ernest Choy,Peter C. Taylor,Michael J. Townsend,Costantino Pitzalis +32 more
TL;DR: In this paper, a comprehensive RNA sequencing analysis of the molecular pathways that drive early RA progression in the disease tissue (synovium), comparing matched peripheral blood RNA-seq in a large cohort of early treatment-naive patients, namely, the Pathobiology of Early Arthritis Cohort (PEAC).
Journal ArticleDOI
Synovial cellular and molecular signatures stratify clinical response to csDMARD therapy and predict radiographic progression in early rheumatoid arthritis patients
Frances Humby,Myles Lewis,Nandhini Ramamoorthi,Jason A. Hackney,Michael R. Barnes,Michele Bombardieri,A. Francesca Setiadi,Stephen Kelly,F Bene,M DiCicco,Sudeh Riahi,V. Rocher,Nora Ng,Ilias Lazarou,Rebecca Hands,Désirée van der Heijde,Robert Landewé,Annette H M van der Helm-van Mil,Alberto Cauli,Iain B. McInnes,Christopher D. Buckley,Ernest Choy,Peter C. Taylor,Michael J. Townsend,Costantino Pitzalis +24 more
TL;DR: At disease presentation, prior to pathology modulation by therapy, the presence of specific cellular/molecular synovial signatures that delineate disease severity/progression and therapeutic response may pave the way to more precise definition of RA taxonomy, therapeutic targeting and improved outcomes.