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Nadia R. Roan
Researcher at University of California, San Francisco
Publications - 110
Citations - 3017
Nadia R. Roan is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Biology & Immune system. The author has an hindex of 25, co-authored 88 publications receiving 2116 citations. Previous affiliations of Nadia R. Roan include University of California, Berkeley & Gladstone Institutes.
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Journal ArticleDOI
The Cationic Properties of SEVI Underlie Its Ability To Enhance Human Immunodeficiency Virus Infection
Nadia R. Roan,Jan Münch,Nathalie J. Arhel,Walther Mothes,Jason Neidleman,Akiko Kobayashi,Karen Smith-McCune,Frank Kirchhoff,Warner C. Greene +8 more
TL;DR: It is demonstrated that the intrinsic positive charges of SEVI facilitate virion attachment to and fusion with target cells and suggest that SEVI enhances viral infection by serving as a polycationic bridge that neutralizes the negative charge repulsion that exists between HIV virions and target cells.
Journal ArticleDOI
SARS-CoV-2-Specific T Cells Exhibit Phenotypic Features of Helper Function, Lack of Terminal Differentiation, and High Proliferation Potential.
Jason Neidleman,Jason Neidleman,Xiaoyu Luo,Julie Frouard,Julie Frouard,Guorui Xie,Guorui Xie,Gurjot Gill,Ellen Stein,Matthew McGregor,Matthew McGregor,Tongcui Ma,Tongcui Ma,Ashley F. George,Ashley F. George,Astrid Kosters,Warner C. Greene,Warner C. Greene,Joshua Vasquez,Eliver Ghosn,Sulggi A. Lee,Sulggi A. Lee,Nadia R. Roan,Nadia R. Roan +23 more
TL;DR: It is suggested that long-lived and robust T cell immunity is generated following natural SARS-CoV-2 infection, and support an important role for Sars-Cov-2-specific T cells in host control of COVID-19.
Journal ArticleDOI
Peptides released by physiological cleavage of semen coagulum proteins form amyloids that enhance HIV infection.
Nadia R. Roan,Janis A. Müller,Haichuan Liu,Simon Chu,Franziska Arnold,Christina M. Stürzel,Paul Walther,Ming Dong,H. Ewa Witkowska,Frank Kirchhoff,Jan Münch,Warner C. Greene +11 more
TL;DR: Semen harbors distinct amyloidogenic peptides derived from different precursor proteins that commonly enhance HIV infection and likely contribute to HIV transmission.
Journal ArticleDOI
Semen-mediated enhancement of HIV infection is donor-dependent and correlates with the levels of SEVI.
Kyeong Ae Kim,Maral Yolamanova,Onofrio Zirafi,Nadia R. Roan,Ludger Staendker,Wolf-Georg Forssmann,Adam Burgener,Nathalie Dejucq-Rainsford,Beatrice H. Hahn,George M. Shaw,Warner C. Greene,Frank Kirchhoff,Jan Münch +12 more
TL;DR: It is shown that semen rapidly and effectively enhances the infectivity of HIV-1, HIV-2, and SIV and that SEVI contributes to this effect.
Journal ArticleDOI
Limited cross-variant immunity from SARS-CoV-2 Omicron without vaccination
Rahul K. Suryawanshi,Irene P. Chen,Tongcui Ma,Abdullah Muhammad Syed,N. Brazer,P. Saldhi,Camille R. Simoneau,Alison Ciling,Mir M. Khalid,Bharath K. Sreekumar,Pei-Hung Chen,G. Renuka Kumar,Mauricio Montano,Ronne Gascon,Chia-Lin Tsou,Miguel Garcia-Knight,Alicia Sotomayor-Gonzalez,Venice Servellita,Amelia S. Gliwa,Jenny Nguyen,Inês Silva,B. Milbes,Noah Kojima,Victoria A. Hess,M. Shacreaw,Lauren Lopez,Matthew Brobeck,Fred E. Turner,Frank Soveg,Ashley F. George,Xiaohui Fang,Mazharul I. Maishan,Michael A. Matthay,Mary Kate Morris,Debra A. Wadford,Carly Hanson,Warner C. Greene,Raul Andino,Lee Spraggon,Nadia R. Roan,Charles Y. Chiu,Jennifer A. Doudna,Melanie Ott +42 more
TL;DR: This article showed that Omicron infection enhances pre-existing immunity elicited by vaccines but, on its own, may not confer broad protection against non-Omicron variants in unvaccinated individuals.